Concurrent mapping of an adenovirus 5/SV40 integration site and the U1 snRIMA Cluster (RNU1) within 400 kb of the chromosome region 1p36.1

M. Romani, A. Baldini, E. V. Volpi, I. Casciano, C. Nobile, R. Muresu, M. Siniscalco

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Previous reports from our group suggested the preferential integration of the viral construct Ad5/SV40 at the short arm subtelomeric region of human chromosome 1. The present study narrows the region of viral integration to site 1 p36.1 in a close cytogenetic overlap with the U1 snRNA gene cluster (RNU1) within a distance necessarily smaller than 400 kb as suggested by the size of the YAC in which the two markers were found to coexist. This finding supports the hypothesis that the chromosomal site in question may have a constitutional propensity to genetic recombination.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalCytogenetic and Genome Research
Volume67
Issue number1
DOIs
Publication statusPublished - 1994

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Virus Integration
Adenoviridae
Chromosomes
Chromosomes, Human, Pair 1
Human Chromosomes
Multigene Family
Cytogenetics
Genetic Recombination
U1 small nuclear RNA

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

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Concurrent mapping of an adenovirus 5/SV40 integration site and the U1 snRIMA Cluster (RNU1) within 400 kb of the chromosome region 1p36.1. / Romani, M.; Baldini, A.; Volpi, E. V.; Casciano, I.; Nobile, C.; Muresu, R.; Siniscalco, M.

In: Cytogenetic and Genome Research, Vol. 67, No. 1, 1994, p. 37-40.

Research output: Contribution to journalArticle

Romani, M. ; Baldini, A. ; Volpi, E. V. ; Casciano, I. ; Nobile, C. ; Muresu, R. ; Siniscalco, M. / Concurrent mapping of an adenovirus 5/SV40 integration site and the U1 snRIMA Cluster (RNU1) within 400 kb of the chromosome region 1p36.1. In: Cytogenetic and Genome Research. 1994 ; Vol. 67, No. 1. pp. 37-40.
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