Conditional survival of patients with urothelial carcinoma of the urinary bladder treated with radical cystectomy

Maxine Sun, Firas Abdollah, Marco Bianchi, Quoc Dien Trinh, Shahrokh F. Shariat, Claudio Jeldres, Zhe Tian, Jens Hansen, Alberto Briganti, Markus Graefen, Francesco Montorsi, Paul Perrotte, Pierre I. Karakiewicz

Research output: Contribution to journalArticle

Abstract

Aim of study: To examine the impact of survival probability according to duration of survivorship following radical cystectomy (RC) in patients diagnosed with urothelial carcinoma of the urinary bladder (UCUB). Methods: Overall, 4991 UCUB patients who underwent RC were abstracted. The cumulative survival estimates were used to generate conditional survival rates. Cox regression analyses were performed for prediction of cancer-specific mortality (CSM), according to duration of survivorship. Results: The five-year CSM-free survival rate was 63.9% at RC, and increased to 71.0%, 77.5%, 81.7%, 85.9% and 86.3% in patients who survived ≥1, 2, 3, 4 and 5 years, respectively. Patients with pT2-4 disease benefitted from the highest increase in survivorship two years after RC. The same findings were recorded according to patients' nodal status. Conclusion: The survival of the first two years after RC markedly improves individual patient prognosis. The prognostic gains differ according to patient and tumour characteristics.

Original languageEnglish
Pages (from-to)1503-1511
Number of pages9
JournalEuropean Journal of Cancer
Volume48
Issue number10
DOIs
Publication statusPublished - Jul 2012

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Keywords

  • Conditional survival
  • Radical cystectomy
  • Urothelial carcinoma of the urinary bladder

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sun, M., Abdollah, F., Bianchi, M., Trinh, Q. D., Shariat, S. F., Jeldres, C., Tian, Z., Hansen, J., Briganti, A., Graefen, M., Montorsi, F., Perrotte, P., & Karakiewicz, P. I. (2012). Conditional survival of patients with urothelial carcinoma of the urinary bladder treated with radical cystectomy. European Journal of Cancer, 48(10), 1503-1511. https://doi.org/10.1016/j.ejca.2011.11.024