Abstract
Aim of study: To examine the impact of survival probability according to duration of survivorship following radical cystectomy (RC) in patients diagnosed with urothelial carcinoma of the urinary bladder (UCUB). Methods: Overall, 4991 UCUB patients who underwent RC were abstracted. The cumulative survival estimates were used to generate conditional survival rates. Cox regression analyses were performed for prediction of cancer-specific mortality (CSM), according to duration of survivorship. Results: The five-year CSM-free survival rate was 63.9% at RC, and increased to 71.0%, 77.5%, 81.7%, 85.9% and 86.3% in patients who survived ≥1, 2, 3, 4 and 5 years, respectively. Patients with pT2-4 disease benefitted from the highest increase in survivorship two years after RC. The same findings were recorded according to patients' nodal status. Conclusion: The survival of the first two years after RC markedly improves individual patient prognosis. The prognostic gains differ according to patient and tumour characteristics.
| Original language | English |
|---|---|
| Pages (from-to) | 1503-1511 |
| Number of pages | 9 |
| Journal | European Journal of Cancer |
| Volume | 48 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Jul 2012 |
Fingerprint
Keywords
- Conditional survival
- Radical cystectomy
- Urothelial carcinoma of the urinary bladder
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Conditional survival of patients with urothelial carcinoma of the urinary bladder treated with radical cystectomy. / Sun, Maxine; Abdollah, Firas; Bianchi, Marco; Trinh, Quoc Dien; Shariat, Shahrokh F.; Jeldres, Claudio; Tian, Zhe; Hansen, Jens; Briganti, Alberto; Graefen, Markus; Montorsi, Francesco; Perrotte, Paul; Karakiewicz, Pierre I.
In: European Journal of Cancer, Vol. 48, No. 10, 07.2012, p. 1503-1511.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Conditional survival of patients with urothelial carcinoma of the urinary bladder treated with radical cystectomy
AU - Sun, Maxine
AU - Abdollah, Firas
AU - Bianchi, Marco
AU - Trinh, Quoc Dien
AU - Shariat, Shahrokh F.
AU - Jeldres, Claudio
AU - Tian, Zhe
AU - Hansen, Jens
AU - Briganti, Alberto
AU - Graefen, Markus
AU - Montorsi, Francesco
AU - Perrotte, Paul
AU - Karakiewicz, Pierre I.
PY - 2012/7
Y1 - 2012/7
N2 - Aim of study: To examine the impact of survival probability according to duration of survivorship following radical cystectomy (RC) in patients diagnosed with urothelial carcinoma of the urinary bladder (UCUB). Methods: Overall, 4991 UCUB patients who underwent RC were abstracted. The cumulative survival estimates were used to generate conditional survival rates. Cox regression analyses were performed for prediction of cancer-specific mortality (CSM), according to duration of survivorship. Results: The five-year CSM-free survival rate was 63.9% at RC, and increased to 71.0%, 77.5%, 81.7%, 85.9% and 86.3% in patients who survived ≥1, 2, 3, 4 and 5 years, respectively. Patients with pT2-4 disease benefitted from the highest increase in survivorship two years after RC. The same findings were recorded according to patients' nodal status. Conclusion: The survival of the first two years after RC markedly improves individual patient prognosis. The prognostic gains differ according to patient and tumour characteristics.
AB - Aim of study: To examine the impact of survival probability according to duration of survivorship following radical cystectomy (RC) in patients diagnosed with urothelial carcinoma of the urinary bladder (UCUB). Methods: Overall, 4991 UCUB patients who underwent RC were abstracted. The cumulative survival estimates were used to generate conditional survival rates. Cox regression analyses were performed for prediction of cancer-specific mortality (CSM), according to duration of survivorship. Results: The five-year CSM-free survival rate was 63.9% at RC, and increased to 71.0%, 77.5%, 81.7%, 85.9% and 86.3% in patients who survived ≥1, 2, 3, 4 and 5 years, respectively. Patients with pT2-4 disease benefitted from the highest increase in survivorship two years after RC. The same findings were recorded according to patients' nodal status. Conclusion: The survival of the first two years after RC markedly improves individual patient prognosis. The prognostic gains differ according to patient and tumour characteristics.
KW - Conditional survival
KW - Radical cystectomy
KW - Urothelial carcinoma of the urinary bladder
UR - http://www.scopus.com/inward/record.url?scp=84862016221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862016221&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2011.11.024
DO - 10.1016/j.ejca.2011.11.024
M3 - Article
C2 - 22196034
AN - SCOPUS:84862016221
VL - 48
SP - 1503
EP - 1511
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 10
ER -