Abstract
Purpose To evaluate the dosimetric changes of parotid glands (PG) during a course of intensity-modulated radiotherapy (IMRT) in head and neck (H&N) cancer patients. Methods Ten patients with H&N cancer treated by IMRT were analyzed. The original treatment plan (CTplan) was transferred to cone-beam computed tomography (CBCT) acquired at the 15th and 20th treatment day (CBCTplan I and II, respectively). ThePGmean dose (D mean), the dose to 50 % of the volume, and the percent of volume receiving 30 and 50 Gy were measured by the dose volume histogram. Results 30 IMRT plans were evaluated (3 plans/patient). All dosimetric end points increased significantly for both PG only when CTplan was compared to CBCT plan I. The Dmean increased significantly only for ipsilateral PG (p = 0.02) at week 3. Conclusion During a course of IMRT, CBCT is a feasible method to check the PG dosimetric variations. Perhaps, the 3rd week of radiotherapy could be considered as the timecheck- point.
| Original language | English |
|---|---|
| Pages (from-to) | 412-415 |
| Number of pages | 4 |
| Journal | Clinical and Translational Oncology |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2013 |
Keywords
- Head and neck cancer
- IMRT
- Organ at risk
- Parotid glands
- Radiotherapy
ASJC Scopus subject areas
- Oncology
- Cancer Research
- Medicine(all)