Confined placental mosaicism at chorionic villous sampling: Risk factors and pregnancy outcome

Objective: This study aims to investigate the clinical relevance of confined placental mosaicism (CPM) detected at chorionic villous sampling (CVS) and to identify risk factors for this condition. Method: Women diagnosed with CPM between January 2005 and December 2009 were identified. They were matched to women with unremarkable CVS in a 1:2 ratio by study period and contacted by phone for interview. Results: One hundred fifteen exposed and 230 unexposed women were selected. Baseline characteristics did not differ between the study groups apart from maternal body mass index, which is mildly higher in the CPM group (+0.6kg/m², p=0.047), and maternal age, which is higher in women with type III CPM (39.7±2.6 vs 37.1±3.2years, p=0.005). A higher frequency of gestational hypertension was observed in exposed women (10% vs 2%) (p=0.003). Small for gestational age newborns were more frequent in women with type I CPM (15% vs 5%, p=0.03). The incidence of other main complications of pregnancy (stillbirth, prematurity, preeclampsia and gestational diabetes mellitus) was similar. Neonatal complications and subsequent infant health and development did not also differ. Conclusion: Women with the diagnosis of CPM at CVS can be generally reassured regarding the course of pregnancy and infant health and development.