Confirmation of the association between high levels of immunoglobulin E food sensitization and eczema in infancy: An international study

D. J. Hill, C. S. Hosking, F. M. De Benedictis, A. P. Oranje, T. L. Diepgen, V. Bauchau, J. O. Warner, C. K. Naspitz, F. E R Simons, T. L. Diepgen, U. Wahn, F. M. De Benedictis, E. Von Mutius, J. O. Warner, T. L. Diepgen, C. Grüber, D. Hill, F. Rancé, M. Wajskop, M. De LonguevilleC. Fortpied, M. E. Pinelli, F. Staelens, M. Gold, P. Quinn, H. Marshall, M. Kummerow, D. Hill, R. Heine, D. Bannister, P. Sly, R. Loh, A. Halbert, T. Douglas, S. Stick, P. Van Asperen, A. Kakakios, W. Nightingale, K. Mckay, M. Zach, A. Pfleger, E. M. Varga, W. Emminger, B. Käfer, D. Stefanovic, V. Plank, A. De Moor, K. Desager, M. Hagendorens, L. De Raeve, A. Malfoort, O. Rybníček, J. Chládkov́a, T. Chyba, F. Kopřiva, O. Škopková, V. Balcárek, H. Honomichlova, P. Honomichlová-Houdkova, P. Honomichl, V. Petru, A. Carbolova, K. Kopecká, P. Pohunek, T. Svobodova, V. Špičák, K. Kopecka, M. Maltulka, M. Špiřáková, S. Kynclova, E. Billard, M. Robert, H. Cartier, M. C. Castelain, F. Payot, J. Levy, M. Ruer, F. Cambazard, J. L. Perrot, L. Fond, M. Pétrus, F. Rancé, G. Le Manach, J. Robert, F. Friedrichs, C. Pfannenstiel, S. Jobst, H. Schatz, B. Niggemann, C. Grüber, H. G. Bresser, K. Landwehr, U. Schauer, T. Zimmermann, M. Hertl, T. Froehlich-Krapf, D. Bulle, E. Rietschel, L. Lange, S. Müller, S. Van Koningsbruggen, D. Abeck, J. Ring, I. Forer, M. Vogel, S. Fischer, I. Tichmann-Schumann, R. Wörnle, H. Kiekens, R. Dolderer, A. Von Berg, B. Albrecht, C. Bollrath, F. Franceschini, L. Pietroni, B. Bruschi, L. Armenio, M. C. Massagli, L. Brunetti, P. Fiermonte, M. Rana, L. Granieri, M. Loré, M. Masi, A. Patriza, F. Specchia, B. Bigucci, G. Ricci, A. Miniachi, M. Duse, V. Porteri, C. Belotti, G. Barberio, V. Tiralongo, D. Vita, R. Feliciotto, L. Caminiti, A. Fiocchi, T. Sarratud, L. Terracciano, A. De Chiara, A. Capristo, C. Capristo, N. Maiello, F. Decimo, A. Rocco, M. Miraglia Del Giudice, G. Marseglia, G. Lombardini, A. Ricci, S. Caimmi, A. Napoli, C. Tzialla, V. Ghiglione, E. Galli, P. Giampietro, G. Mancino, E. Arabito, P. Rossi, M. Chianca, V. Moschese, L. Chini, A. Swiatly, A. Szczawinska-Popkonyl, M. Kulesza-Kazecka, G. Cavagni, A. Spattini, S. Pastorelli, A. Messori, A. Boner, E. Fasoli, I. Romei, L. Alfonsi, J. Rijntjes, H. Sillevis Smitt, J. C. Van Nierop, E. J. Duiverman, M. Brouwer, A. Niewenhuis, B. Rottier, S. Van Der Heide, A. Oranje, P. Kemperman, T. Breedijk, F. De Waard-van Der Spek, C. Bruynzeel-Komen, S. Pasmans, Y. Meijer, A. E. Flinterman, M. Kaczmarski, B. Cudowska, J. Wasilewska, E. Matuszfwska, T. Malaczynska, B. Klajna-Kraluk, J. Sokalska, E. Masnica-Wasylkowska, I. Biegun-Awramineko, M. Chlon, T. Latos, E. Pomaranska, G. Gaszczyk, B. Makuch, J. Stanisz, J. Bokiej, G. Lis, E. Cichocka-Jarosz, I. Glodzik, T. Szczerbinski, D. Chlebna-Sokol, A. Stanczyk, J. Wlazlowski, I. Ligenza, B. Kamer, K. Pyziak, R. Pasowska, J. Zwaigzne-Racynska, A. Emeryk, H. Milanowska, G. Zywicka, M. Bartkowiak-Emeryk, E. Chojna, J. Alkiewicz, A. Breborowicz, R. Kurzawa, A. Wojcik, U. Jedrys-Klucjasz, E. Urbanek-Jozwik, L. Dymek, A. Dymek, A. Bozek, D. Chmielewska-Szewczyk, J. Lange, J. Peradzynska, M. Kulus, E. Najberg, E. Nowicka, A. Chrupek, A. Boznanski, E. Willak-Janc, A. Latkowska, E. Sikorska, M. T. Jarlinska, J. L. Eseverri Asin, E. Mũnoz, M. T. Giner, A. M. Plaza, M. Piquer Gilbert, E. P. Díaz González, M. A. Martín, J. I. Sierra, J. L. Corzo, E. Rojas, R. Santos, M. Bosque Garcia, L. Valdesoiro, O. Asensio, H. Larramona, A. Nieto Garcia, L. Caballero, R. Pamies, F. Oliver, M. Evole, A. Mazón, A. Puterman, A. J. Morris, J. H. Vermeulen, H. C. Weber, R. P. Edson, I. Pollock, A. Postma, L. F G Minders, O. F. Jooma, M. Suleman, Z. F A Vawda, S. H. Mahomedy, P. Potter, S. Emmanuel, A. F. Marian, D. Hawarden, C. Motala, P. J. White, H. C. Weber, R. P. Edson, S. J. Reyneke, W. Havemann, A. Morison, N. Clarke, R. Clifford, H. Arshad, [No Value] Pereira, G. Roberts, J. O B Hourihane, G. Roberts, K. Foote, M. T. Sollis

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Studies of Australian infants have reported that more than 80% of those with moderate atopic eczema (AE) have high levels of IgE food sensitization (IgE-FS) that are commonly associated with IgE food allergy. Objectives: To explore the relationship between high levels of IgE-FS and AE in a large cohort of young children with eczema participating in a multi-centre, international study. Methods: Two thousand one hundred and eighty-four subjects (mean age 17.6 months, range 11.8-25.4; 1246 males) with active eczema from atopic families from 94 centres in 12 countries were studied. Clinical history, Scoring Atopic Dermatitis index as a measure of eczema severity and CAP-FEIA measurements for total IgE and IgE antibody levels to cow milk, egg and peanut were entered into a database. If CAP-FEIA levels exceeded previously reported age-specific cut-off levels for 95% positive predictive values (PPVs) for food allergy, subjects were defined as having high-risk IgE-FS (HR-IgE-FS). Results: Serum was available from 2048 patients; 55.5% were atopic. The frequency of HR-IgE-FS to milk, egg and/or peanut was the greatest in patients whose eczema developed in the first 3 months of life and the least in those whose eczema developed after 12 months (P

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalClinical and Experimental Allergy
Volume38
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Atopic eczema
  • Food hypersensitivity
  • Food-specific serum IgE antibody
  • IgE food sensitization
  • Infants

ASJC Scopus subject areas

  • Immunology

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