Conflict-dependent dynamic of subthalamic nucleus oscillations during moral decisions

Manuela Fumagalli, Gaia Giannicola, Manuela Rosa, Sara Marceglia, Claudio Lucchiari, Simona Mrakic-Sposta, Domenico Servello, Claudio Pacchetti, Mauro Porta, Marco Sassi, Roberta Zangaglia, Angelo Franzini, Alberto Albanese, Luigi Romito, Sylvie Piacentini, Stefano Zago, Gabriella Pravettoni, Sergio Barbieri, Alberto Priori

Research output: Contribution to journalArticle

Abstract

Although lesional, neuroimaging, and brain stimulation studies have provided an insight into the neural mechanisms of judgement and decision-making, all these works focused on the cerebral cortex, without investigating the role of subcortical structures such as the basal ganglia. Besides being an effective therapeutic tool, deep brain stimulation (DBS) allows local field potential (LFP) recordings through the stimulation electrodes thus providing a physiological "window" on human subcortical structures. In this study we assessed whether subthalamic nucleus LFP oscillations are modulated by processing of moral conflictual, moral nonconflictual, and neutral statements. To do so, in 16 patients with Parkinson's disease (8 men) bilaterally implanted with subthalamic nucleus (STN) electrodes for DBS, we recorded STN LFPs 4 days after surgery during a moral decision task. During the task, recordings from the STN showed changes in LFP oscillations. Whereas the 14-30 Hz band (beta) changed during the movement executed to perform the task, the 5-13 Hz band (low-frequency) changed when subjects evaluated the content of statements. Low-frequency band power increased significantly more during conflictual than during nonconflictual or neutral sentences. We conclude that STN responds specifically to conflictual moral stimuli, and could be involved in conflictual decisions of all kinds, not only those for moral judgment. LFP oscillations provide novel direct evidence that the neural processing of conflictual decision-making spreads beyond the cortex to the basal ganglia and encompasses a specific subcortical conflict-dependent component.

Original languageEnglish
Pages (from-to)243-256
Number of pages14
JournalSocial Neuroscience
Volume6
Issue number3
DOIs
Publication statusPublished - Jun 2011

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Keywords

  • Conflict
  • Deep brain stimulation
  • Local field potentials
  • Moral decisions
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Development
  • Social Psychology

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