Confocal laser endomicroscopy for prediction of disease relapse in ulcerative colitis: A pilot study

Andrea Buda, Giorgia Hatem, Helmut Neumann, Renata D' Incà, Claudia Mescoli, Pierluca Piselli, John Jackson, Marco Bruno, Giacomo Carlo Sturniolo

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Aims: Neoangiogenesis and increased endothelial permeability are observed as results of chronic intestinal inflammation. However, limited data on microvascular and crypt architecture during remission phases is available. The aim of this prospective investigator blinded cohort study was to assess crypt and microvascular architecture and function in ulcerative colitis by probe based confocal laser endomicroscopy; we also evaluated whether these findings may have the potential to predict disease relapse. Methods: 19 ulcerative colitis patients in clinical and endoscopic remission and 19 controls were studied. A computer based image processing technique was applied to construct 20 mosaicing image sets from each subject. Remitting patients were sub-grouped into either inactive or quiescent disease according to histology. Results: Pericrypt fluorescence (p.

Original languageEnglish
Pages (from-to)304-311
Number of pages8
JournalJournal of Crohn's & colitis
Volume8
Issue number4
DOIs
Publication statusPublished - 2014

Keywords

  • Confocal laser endomicroscopy
  • Microvasculature
  • Mucosal healing
  • Relapse
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

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