Confocal laser endomicroscopy for the differential diagnosis of ulcerative colitis and Crohn's disease: A pilot study

Gian Eugenio Tontini, Jonas Mudter, Michael Vieth, Raja Atreya, Claudia Günther, Yurdagül Zopf, Dane Wildner, Ralf Kiesslich, Maurizio Vecchi, Markus F. Neurath, Helmut Neumann

Research output: Contribution to journalArticlepeer-review

Abstract

Background and study aim: The differential diagnosis of ulcerative colitis from Crohn's disease is of pivotal importance for the management of inflammatory bowel diseases, as both entities involve specific therapeutic management strategies. Confocal laser endomicroscopy (CLE) allows on-demand, in vivo characterization of architectural and cellular details during endoscopy. The aim of this study was to assess the efficacy of CLE to differentiate between ulcerative colitis and Crohn's disease. Patients and methods: This was a prospective study involving consecutive patients with a well-established diagnosis of ulcerative colitis or Crohn's disease who underwent colonoscopy with fluorescein-aided confocal imaging. Results: Overall, 79 patients were included (40 Crohn's disease, 39 ulcerative colitis). CLE findings in patients with Crohn's disease, showed significantly more discontinuous inflammation (87.5 % vs. 5.1 %), focal cryptitis (75.0 % vs. 12.8 %), and discontinuous crypt architectural abnormality (87.5 % vs. 10.3 %) than in ulcerative colitis (P 

Original languageEnglish
Pages (from-to)437-443
Number of pages7
JournalEndoscopy
Volume47
Issue number5
DOIs
Publication statusPublished - May 1 2015

ASJC Scopus subject areas

  • Gastroenterology

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