Conformal and stereotactic radiotherapy in hepatocellular carcinoma

Marta Scorsetti, Mario Bignardi

Research output: Contribution to journalArticlepeer-review

Abstract

Historically Radiation Therapy (RT) had played a minor role in the treatment of hepatocellular carcinoma, especially because of toxicity related to conventional techniques. However, high radiation doses can now be given safely by means of 3D-conformal techniques and other more specialized techniques. 3D-conformal RT in which both target definitions and treatment planning are based on three-dimensional image data sets, provided good local control in several series. As an evolution of cranial radiosurgery, stereotactic body radiation therapy (SBRT) is currently being employed as a new tool for the treatment of HCC, as it offers the opportunity of achieving radioablation for tumours up to 6 cm in diameter qith a minimal risk of radiation induced liver disease. SBRT is distinguished by the fact that both planning and treatment are guided by reference to a system of external stereotactic coordinates. As a consequence, SBRT may succeed in minimizing geometric treatment uncertainities, thus allowing the delivery of high doses to the target given inb a small numeber of fraction. In several published series of SBRT for HCC, actuarial 5-year local control rates higher thean 80% have been achieved. In short radiation therapy should be considered as a useful addition to the treatment spectrum of HCC.

Original languageEnglish
Pages (from-to)104-110
Number of pages7
JournalPoliclinico - Sezione Medica
Volume114
Issue number3
Publication statusPublished - Sep 2007

Keywords

  • Conformal radiotherapy
  • Hepatocellular carcinoma
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Medicine(all)

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