Abstract
There is increasing evidence that cardiac dysfunction is a key contributor to CDH pathophysiology. Dysfunction in both right and left ventricles is common in the early neonatal period, contributes to clinical disease severity, and is associated with adverse outcomes including death and ECMO use. Early and routine assessment of ventricular function and pulmonary artery pressure may guide individualized clinical decision-making, including use of pulmonary vasodilators, cardiotropes, ECMO, and timing of surgical repair. Minimizing cardiac dysfunction, whether by prenatal, postnatal or perinatal treatment strategies, may lead to improved outcome in CDH.
| Original language | English |
|---|---|
| Journal | Seminars in Perinatology |
| DOIs | |
| Publication status | E-pub ahead of print - Jul 30 2019 |
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Cite this
Congenital diaphragmatic hernia-associated cardiac dysfunction. / Patel, Neil; Massolo, Anna Claudia; Kipfmueller, Florian.
In: Seminars in Perinatology, 30.07.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Congenital diaphragmatic hernia-associated cardiac dysfunction
AU - Patel, Neil
AU - Massolo, Anna Claudia
AU - Kipfmueller, Florian
N1 - Copyright © 2019 Elsevier Inc. All rights reserved.
PY - 2019/7/30
Y1 - 2019/7/30
N2 - There is increasing evidence that cardiac dysfunction is a key contributor to CDH pathophysiology. Dysfunction in both right and left ventricles is common in the early neonatal period, contributes to clinical disease severity, and is associated with adverse outcomes including death and ECMO use. Early and routine assessment of ventricular function and pulmonary artery pressure may guide individualized clinical decision-making, including use of pulmonary vasodilators, cardiotropes, ECMO, and timing of surgical repair. Minimizing cardiac dysfunction, whether by prenatal, postnatal or perinatal treatment strategies, may lead to improved outcome in CDH.
AB - There is increasing evidence that cardiac dysfunction is a key contributor to CDH pathophysiology. Dysfunction in both right and left ventricles is common in the early neonatal period, contributes to clinical disease severity, and is associated with adverse outcomes including death and ECMO use. Early and routine assessment of ventricular function and pulmonary artery pressure may guide individualized clinical decision-making, including use of pulmonary vasodilators, cardiotropes, ECMO, and timing of surgical repair. Minimizing cardiac dysfunction, whether by prenatal, postnatal or perinatal treatment strategies, may lead to improved outcome in CDH.
U2 - 10.1053/j.semperi.2019.07.007
DO - 10.1053/j.semperi.2019.07.007
M3 - Review article
C2 - 31420110
JO - Seminars in Perinatology
JF - Seminars in Perinatology
SN - 0146-0005
ER -