Congenital diaphragmatic hernia-associated cardiac dysfunction

Neil Patel, Anna Claudia Massolo, Florian Kipfmueller

Research output: Contribution to journalReview article

Abstract

There is increasing evidence that cardiac dysfunction is a key contributor to CDH pathophysiology. Dysfunction in both right and left ventricles is common in the early neonatal period, contributes to clinical disease severity, and is associated with adverse outcomes including death and ECMO use. Early and routine assessment of ventricular function and pulmonary artery pressure may guide individualized clinical decision-making, including use of pulmonary vasodilators, cardiotropes, ECMO, and timing of surgical repair. Minimizing cardiac dysfunction, whether by prenatal, postnatal or perinatal treatment strategies, may lead to improved outcome in CDH.

Original languageEnglish
JournalSeminars in Perinatology
DOIs
Publication statusE-pub ahead of print - Jul 30 2019

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Heart Ventricles
Ventricular Function
Vasodilator Agents
Pulmonary Artery
Pressure
Lung
Congenital Diaphragmatic Hernias
Clinical Decision-Making

Cite this

Congenital diaphragmatic hernia-associated cardiac dysfunction. / Patel, Neil; Massolo, Anna Claudia; Kipfmueller, Florian.

In: Seminars in Perinatology, 30.07.2019.

Research output: Contribution to journalReview article

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PY - 2019/7/30

Y1 - 2019/7/30

N2 - There is increasing evidence that cardiac dysfunction is a key contributor to CDH pathophysiology. Dysfunction in both right and left ventricles is common in the early neonatal period, contributes to clinical disease severity, and is associated with adverse outcomes including death and ECMO use. Early and routine assessment of ventricular function and pulmonary artery pressure may guide individualized clinical decision-making, including use of pulmonary vasodilators, cardiotropes, ECMO, and timing of surgical repair. Minimizing cardiac dysfunction, whether by prenatal, postnatal or perinatal treatment strategies, may lead to improved outcome in CDH.

AB - There is increasing evidence that cardiac dysfunction is a key contributor to CDH pathophysiology. Dysfunction in both right and left ventricles is common in the early neonatal period, contributes to clinical disease severity, and is associated with adverse outcomes including death and ECMO use. Early and routine assessment of ventricular function and pulmonary artery pressure may guide individualized clinical decision-making, including use of pulmonary vasodilators, cardiotropes, ECMO, and timing of surgical repair. Minimizing cardiac dysfunction, whether by prenatal, postnatal or perinatal treatment strategies, may lead to improved outcome in CDH.

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