Congenital estrogen deficiency: In search of the estrogen role in human male reproduction

Vincenzo Rochira, Antonio Balestrieri, Bruno Madeo, Enrica Baraldi, Marco Faustini-Fustini, Antonio R M Granata, Cesare Carani

Research output: Contribution to journalArticle


Recently, a remarkable progress has been made in our understanding about the role of sex steroids in male physiology. In this paper, we consider the clinical aspects of congenital estrogen deficiency - notably, estrogen resistance and aromatase deficiency - in men and we discuss both well-established and supposed estrogen roles in the human male reproductive function. These topics include the role of estrogens in the control of gonadotropin secretion, in male fertility determination and psychosexual behavior. Briefly, estrogens play a pivotal role in the control of serum gonadotropin concentrations in the human male. Furthermore, a possible role of estrogens on both human male fertility and sexuality has also been suggested by recent studies, even though the available data are far from being conclusive. Conversely, for what concern fertility and sexual behavior, a well-established effect of estrogens has been provided by recent studies on male rodents, which show impaired sexual behavior and fertility as a consequence of estrogen defect.

Original languageEnglish
Pages (from-to)107-115
Number of pages9
JournalMolecular and Cellular Endocrinology
Issue number1-2
Publication statusPublished - Jun 19 2001


  • Estrogen deficiency
  • Fertility
  • Gender-identity
  • Gonadotropin feedback
  • Male sexual behavior
  • Sexual orientation
  • Spermatogenesis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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