Congenital fibrosarcoma in complete remission with somatostatin, bromocriptine, retinoids, vitamin D3, Vitamin E, Vitamin C, Melatonin, Calcium, chondroitin sulfate associated with low doses of Cyclophosphamide in a 14-year follow up

Giuseppe Di Bella, Rosilde Toscano, Alessandro Ricchi, Biagio Colori

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

At birth, a male child presented a 6 cm tumour in the right leg. The tumour was partially removed after just 12 days. Histology showed a congenital fibrosarcoma associated with reactive lymphadenitis. A first cycle of adjuvant chemotherapy did not prevent the rapid progression of the disease. Subsequent evaluation for surgical removal raised serious concerns due to the need for a major operation involving total amputation of the right leg and hemipelvectomy. Since surgery could not exclude the possibility of disease recurrence and since the traditional cycles of chemotherapy did not offer any possibility of a cure, the parents opted for the Di Bella Method. The combined use of Somatostatin, Melatonin, Retinoids solubilized in Vit. E, Vit. C, Vit. D3, Calcium, and Chondroitin sulfate associated with low doses of Cyclophosphamide resulted in a complete objective response, still present 14 years later, with no toxicity and without the need for hospitalization, allowing a normal quality of life and perfectly normal adolescent psycho-physical development.

Original languageEnglish
Pages (from-to)725-733
Number of pages9
JournalNeuroendocrinology Letters
Volume36
Issue number8
Publication statusPublished - 2015

Fingerprint

Calcium Sulfate
Bromocriptine
Chondroitin Sulfates
Fibrosarcoma
Cholecalciferol
Retinoids
Melatonin
Somatostatin
Vitamin E
Cyclophosphamide
Ascorbic Acid
Leg
Hemipelvectomy
Lymphadenitis
Adjuvant Chemotherapy
Amputation
Disease Progression
Neoplasms
Histology
Hospitalization

Keywords

  • Melatonin
  • Retinoid
  • Sarcoma
  • Somatostatin
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology
  • Endocrine and Autonomic Systems
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology

Cite this

@article{03f2514332f9429bb642b4d3732bab25,
title = "Congenital fibrosarcoma in complete remission with somatostatin, bromocriptine, retinoids, vitamin D3, Vitamin E, Vitamin C, Melatonin, Calcium, chondroitin sulfate associated with low doses of Cyclophosphamide in a 14-year follow up",
abstract = "At birth, a male child presented a 6 cm tumour in the right leg. The tumour was partially removed after just 12 days. Histology showed a congenital fibrosarcoma associated with reactive lymphadenitis. A first cycle of adjuvant chemotherapy did not prevent the rapid progression of the disease. Subsequent evaluation for surgical removal raised serious concerns due to the need for a major operation involving total amputation of the right leg and hemipelvectomy. Since surgery could not exclude the possibility of disease recurrence and since the traditional cycles of chemotherapy did not offer any possibility of a cure, the parents opted for the Di Bella Method. The combined use of Somatostatin, Melatonin, Retinoids solubilized in Vit. E, Vit. C, Vit. D3, Calcium, and Chondroitin sulfate associated with low doses of Cyclophosphamide resulted in a complete objective response, still present 14 years later, with no toxicity and without the need for hospitalization, allowing a normal quality of life and perfectly normal adolescent psycho-physical development.",
keywords = "Melatonin, Retinoid, Sarcoma, Somatostatin, Vitamin D",
author = "{Di Bella}, Giuseppe and Rosilde Toscano and Alessandro Ricchi and Biagio Colori",
year = "2015",
language = "English",
volume = "36",
pages = "725--733",
journal = "Neuroendocrinology Letters",
issn = "0172-780X",
publisher = "Maghira and Maas Publications",
number = "8",

}

TY - JOUR

T1 - Congenital fibrosarcoma in complete remission with somatostatin, bromocriptine, retinoids, vitamin D3, Vitamin E, Vitamin C, Melatonin, Calcium, chondroitin sulfate associated with low doses of Cyclophosphamide in a 14-year follow up

AU - Di Bella, Giuseppe

AU - Toscano, Rosilde

AU - Ricchi, Alessandro

AU - Colori, Biagio

PY - 2015

Y1 - 2015

N2 - At birth, a male child presented a 6 cm tumour in the right leg. The tumour was partially removed after just 12 days. Histology showed a congenital fibrosarcoma associated with reactive lymphadenitis. A first cycle of adjuvant chemotherapy did not prevent the rapid progression of the disease. Subsequent evaluation for surgical removal raised serious concerns due to the need for a major operation involving total amputation of the right leg and hemipelvectomy. Since surgery could not exclude the possibility of disease recurrence and since the traditional cycles of chemotherapy did not offer any possibility of a cure, the parents opted for the Di Bella Method. The combined use of Somatostatin, Melatonin, Retinoids solubilized in Vit. E, Vit. C, Vit. D3, Calcium, and Chondroitin sulfate associated with low doses of Cyclophosphamide resulted in a complete objective response, still present 14 years later, with no toxicity and without the need for hospitalization, allowing a normal quality of life and perfectly normal adolescent psycho-physical development.

AB - At birth, a male child presented a 6 cm tumour in the right leg. The tumour was partially removed after just 12 days. Histology showed a congenital fibrosarcoma associated with reactive lymphadenitis. A first cycle of adjuvant chemotherapy did not prevent the rapid progression of the disease. Subsequent evaluation for surgical removal raised serious concerns due to the need for a major operation involving total amputation of the right leg and hemipelvectomy. Since surgery could not exclude the possibility of disease recurrence and since the traditional cycles of chemotherapy did not offer any possibility of a cure, the parents opted for the Di Bella Method. The combined use of Somatostatin, Melatonin, Retinoids solubilized in Vit. E, Vit. C, Vit. D3, Calcium, and Chondroitin sulfate associated with low doses of Cyclophosphamide resulted in a complete objective response, still present 14 years later, with no toxicity and without the need for hospitalization, allowing a normal quality of life and perfectly normal adolescent psycho-physical development.

KW - Melatonin

KW - Retinoid

KW - Sarcoma

KW - Somatostatin

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=84969802568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969802568&partnerID=8YFLogxK

M3 - Article

C2 - 26921571

AN - SCOPUS:84969802568

VL - 36

SP - 725

EP - 733

JO - Neuroendocrinology Letters

JF - Neuroendocrinology Letters

SN - 0172-780X

IS - 8

ER -