Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi

Victor Desmond Mandel, Flavia Persechino, Alberto Berardi, Giovanni Ponti, Silvana Ciardo, Maria Cecilia Rossi, Giovanni Pellacani, Francesca Farnetani

Research output: Contribution to journalArticlepeer-review


Background: Glioblastoma multiforme (GBM) is the deadliest malignant primary brain tumor in adults. GBM develops primarily in the cerebral hemispheres but can develop in other parts of the central nervous system. Its congenital variant is a very rare disease with few cases described in literature. Case presentation: We describe the case of a patient with congenital GBM who developed eruptive disseminated Spitz nevi (EDSN) after chemotherapy. Few cases of EDSN have been described in literature and this rare clinical variant, which occurs predominantly in adults, is characterized by multiple Spitz nevi in the trunk, buttocks, elbows and knees. There is no satisfactory treatment for EDSN and the best therapeutic choice is considered the clinical observation of melanocytic lesions. Conclusion: We recommend a close follow-up of these patients with clinical observation, dermoscopy and reflectance confocal microscopy (RCM). However, we suggest a surgical excision of the lesions suspected of being malignant.

Original languageEnglish
Article number47
JournalItalian Journal of Pediatrics
Issue number1
Publication statusPublished - May 14 2016
Externally publishedYes


  • Chemotherapy
  • Congenital glioblastoma multiforme
  • Eruptive disseminated Spitz nevi
  • Reflectance confocal microscopy
  • Spitz nevi

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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