Congenital heart block not associated with anti-Ro/La antibodies: Comparison with anti-Ro/La-positive cases

Antonio Brucato, Chiara Grava, Maria Bortolati, Keigo Ikeda, Ornella Milanesi, Rolando Cimaz, Veronique Ramoni, Gabriele Vignati, Stefano Martinelli, Youcef Sadou, Adele Borghi, Angela Tincani, E. K L Chan, Amelia Ruffatti

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To study anti-Ro/La-negative congenital heart block (CHB). Methods. Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods. Results. There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers. Conclusion. Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)1744-1748
Number of pages5
JournalJournal of Rheumatology
Volume36
Issue number8
DOIs
Publication statusPublished - Aug 2009

Keywords

  • Antinuclear antibodies
  • Autoimmune diseases
  • Heart block

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Rheumatology

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