Congenital heart block not associated with anti-Ro/La antibodies: Comparison with anti-Ro/La-positive cases

Antonio Brucato, Chiara Grava, Maria Bortolati, Keigo Ikeda, Ornella Milanesi, Rolando Cimaz, Veronique Ramoni, Gabriele Vignati, Stefano Martinelli, Youcef Sadou, Adele Borghi, Angela Tincani, E. K L Chan, Amelia Ruffatti

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective. To study anti-Ro/La-negative congenital heart block (CHB). Methods. Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods. Results. There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers. Conclusion. Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)1744-1748
Number of pages5
JournalJournal of Rheumatology
Volume36
Issue number8
DOIs
Publication statusPublished - Aug 2009

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Atrioventricular Block
Dilated Cardiomyopathy
Rheumatology
Fetus
SS-A antibodies
Congenital heart block

Keywords

  • Antinuclear antibodies
  • Autoimmune diseases
  • Heart block

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Rheumatology

Cite this

Brucato, A., Grava, C., Bortolati, M., Ikeda, K., Milanesi, O., Cimaz, R., ... Ruffatti, A. (2009). Congenital heart block not associated with anti-Ro/La antibodies: Comparison with anti-Ro/La-positive cases. Journal of Rheumatology, 36(8), 1744-1748. https://doi.org/10.3899/jrheum.080737

Congenital heart block not associated with anti-Ro/La antibodies : Comparison with anti-Ro/La-positive cases. / Brucato, Antonio; Grava, Chiara; Bortolati, Maria; Ikeda, Keigo; Milanesi, Ornella; Cimaz, Rolando; Ramoni, Veronique; Vignati, Gabriele; Martinelli, Stefano; Sadou, Youcef; Borghi, Adele; Tincani, Angela; Chan, E. K L; Ruffatti, Amelia.

In: Journal of Rheumatology, Vol. 36, No. 8, 08.2009, p. 1744-1748.

Research output: Contribution to journalArticle

Brucato, A, Grava, C, Bortolati, M, Ikeda, K, Milanesi, O, Cimaz, R, Ramoni, V, Vignati, G, Martinelli, S, Sadou, Y, Borghi, A, Tincani, A, Chan, EKL & Ruffatti, A 2009, 'Congenital heart block not associated with anti-Ro/La antibodies: Comparison with anti-Ro/La-positive cases', Journal of Rheumatology, vol. 36, no. 8, pp. 1744-1748. https://doi.org/10.3899/jrheum.080737
Brucato, Antonio ; Grava, Chiara ; Bortolati, Maria ; Ikeda, Keigo ; Milanesi, Ornella ; Cimaz, Rolando ; Ramoni, Veronique ; Vignati, Gabriele ; Martinelli, Stefano ; Sadou, Youcef ; Borghi, Adele ; Tincani, Angela ; Chan, E. K L ; Ruffatti, Amelia. / Congenital heart block not associated with anti-Ro/La antibodies : Comparison with anti-Ro/La-positive cases. In: Journal of Rheumatology. 2009 ; Vol. 36, No. 8. pp. 1744-1748.
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