Le cardiopatie congenite in una popolazione data-based

Translated title of the contribution: Congenital heart defects in Emilia-Roinagna region

Cinzia Magnani, Gian Paolo Garani, Livia Garavelli, Giovanna Bussolati, Giuliano Bosi, Lucia Gambini, Guido Cocchi, Elisa Calzolari

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Altogether 429.139 consecutive births were survcjed during the eighteen years study period by the Emilia-Roinagna Registry. Among these, 2147 newborns with congenital heart defects (CUD) (prevalence 5 per 1000) were detected within the first week of life. There were 1607 isolated CHDs and 540 cases had other associated defects. During the study period an increase in prevalence/rate of CHDs was observed ( from 3.1 per 1000 in 1980 to over 7 per 1000 in 1998), particularly isolated CHDs increased from 2.2 to 6 per 1000, while the prevalence rate of CHDs cases with other associated anomalies was constant ranging from 1 to 2 per 1000. The increase of isolated CHDs was due to the increased number of " minor" lesions such as ventricular (VSD) and atrial septal defect. The apparent increase in birth prevalence of CHD mainly results from improved diagnosis due to widespread use of color-doppler ecocardiography. As in other studies , a significant shift in the sex-ratio has been documented a male predominance in transposition of great arteries, left hypoplastic heart and aortic stenosis (male/female ratio 2.2, 2.3, 4.5 respectively) were found ; while VSD had a slight female excess (male/female ratio 0.96). The study confirmed that the majority of the affected parents were mothers. Thé recurrence risk of a cardiac defect in first degree relatives was 2.3% , while the recurrence risk of isolated conotruncal defects was 3.9%. Out of 47 cases with isolated conotruncal defects 4 had microdeletion of chromosome 22qll.2 and concerning the first degree relatives in one case the father had the deletion without CHD.

Original languageItalian
Pages (from-to)483-486
Number of pages4
JournalActa Biomedica
Volume71
Issue numberSUPPL. 1
Publication statusPublished - 2000

Fingerprint

Congenital Heart Defects
Parturition
Recurrence
Transposition of Great Vessels
Atrial Heart Septal Defects
Ventricular Heart Septal Defects
Aortic Valve Stenosis
Sex Ratio
Fathers
Registries
Color
Chromosomes
Parents
Mothers
Newborn Infant

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Magnani, C., Garani, G. P., Garavelli, L., Bussolati, G., Bosi, G., Gambini, L., ... Calzolari, E. (2000). Le cardiopatie congenite in una popolazione data-based. Acta Biomedica, 71(SUPPL. 1), 483-486.

Le cardiopatie congenite in una popolazione data-based. / Magnani, Cinzia; Garani, Gian Paolo; Garavelli, Livia; Bussolati, Giovanna; Bosi, Giuliano; Gambini, Lucia; Cocchi, Guido; Calzolari, Elisa.

In: Acta Biomedica, Vol. 71, No. SUPPL. 1, 2000, p. 483-486.

Research output: Contribution to journalArticle

Magnani, C, Garani, GP, Garavelli, L, Bussolati, G, Bosi, G, Gambini, L, Cocchi, G & Calzolari, E 2000, 'Le cardiopatie congenite in una popolazione data-based', Acta Biomedica, vol. 71, no. SUPPL. 1, pp. 483-486.
Magnani C, Garani GP, Garavelli L, Bussolati G, Bosi G, Gambini L et al. Le cardiopatie congenite in una popolazione data-based. Acta Biomedica. 2000;71(SUPPL. 1):483-486.
Magnani, Cinzia ; Garani, Gian Paolo ; Garavelli, Livia ; Bussolati, Giovanna ; Bosi, Giuliano ; Gambini, Lucia ; Cocchi, Guido ; Calzolari, Elisa. / Le cardiopatie congenite in una popolazione data-based. In: Acta Biomedica. 2000 ; Vol. 71, No. SUPPL. 1. pp. 483-486.
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