Ipotiroidismo congenito: Follow-up neuropsichico in bambini identificati mediante screening neonatale

Translated title of the contribution: Congenital hypothyroidism: Neuropsychological follow-up in children identified by neonatal screening

G. Weber, V. Siragusa, G. F. Rondanini, R. Rovelli, C. Lenti, J. Colombini, P. Manzoni, S. Mora, G. Chiumello

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the present study was to investigate the neuropsychological development in Italian children with congenital hypothyroidism (C.H.) identified by neonatal screening. Biochemical, strumental and anamnestic parameters were also related to neuropsychological performance to ascertain whether they are predictive of the neuropsychological outcome. Eighty-eight hypothyroid children were included in the present study (24 boys and 64 girls; cross-sectional study). We studied neuropsychological behaviors in 64 patients examined at regular intervals of follow-up. The relationships between psychological outcome and T4, FT 4, thyroglobuline, age at diagnosis, starting dose of L-Thyroxine, femoral epiphyseal knee surface and social rank have been studied. Results of mental development scores, evaluated at different ages, showed that 97% of the children had IQ values within the normal range. Motor development was developed in 18% of the patients at 6 and 12 months, but reached a normal score around 18-24 months of age. We found a significant correlation between IQ and motor development quotient at three years of age. We did not find variables predictive of the psychological outcome in C.H., even though the role of C.H. etiology and social class is uncertain. In conclusion neuropsychological development in children with C.H. identified by neonatal screening was within normal limits.

Translated title of the contributionCongenital hypothyroidism: Neuropsychological follow-up in children identified by neonatal screening
Original languageItalian
Pages (from-to)768-772
Number of pages5
JournalRivista Italiana di Pediatria
Volume22
Issue number5
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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