Congenital myopathy with type 2 A muscle fiber uniformity and smallness

A. Gallanti, A. Prelle, L. Chianese, S. Barbieri, S. Jann, S. Schiaffino, A. Comini, E. Scarpini, G. Pellegrini, M. Moggio, G. Scarlato

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a 12-year-old girl with congenital myopathy. ATPase histochemical reactions and immunocytochemical analysis of muscle fiber-type composition with monoclonal antibodies against slow, fast (2 A and 2 B) and fetal myosin demonstrate that this congenital disease is characterized by type 2 A muscle fiber uniformity and smallness. This is an unusual feature for a congenital myopathy in which the fiber type predominance, when present, is confined to type I.

Original languageEnglish
Pages (from-to)10-13
Number of pages4
JournalNeuropediatrics
Volume23
Issue number1
Publication statusPublished - 1992

Keywords

  • Congenital myopathies
  • Myosin
  • Type 2 A fibers

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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