Congenital pulmonary malformations: Metabolomic profile of lung phenotype in infants

Gloria Pelizzo, Maria Chiara Mimmi, Maurizio Ballico, Mario Marotta, Ilaria Goruppi, Jose Louis Peiro, Elisa Zambaiti, Federico Costanzo, Erika Andreatta, Elena Tonin, Valeria Calcaterra

Research output: Contribution to journalArticle

Abstract

Background: The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy.Methods: Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution 1H NMR-spectroscopy.Results: Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample.Conclusions: Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume29
Issue number1
DOIs
Publication statusPublished - Jan 2 2016

Keywords

  • Congenital lung malformations
  • Metabolomic
  • Translational research

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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  • Cite this

    Pelizzo, G., Mimmi, M. C., Ballico, M., Marotta, M., Goruppi, I., Peiro, J. L., Zambaiti, E., Costanzo, F., Andreatta, E., Tonin, E., & Calcaterra, V. (2016). Congenital pulmonary malformations: Metabolomic profile of lung phenotype in infants. Journal of Maternal-Fetal and Neonatal Medicine, 29(1), 143-147. https://doi.org/10.3109/14767058.2014.991708