Congenital short QT syndrome

Lia Crotti, Erika Taravelli, Giulia Girardengo, Peter J. Schwartz

Research output: Contribution to journalArticlepeer-review

Abstract

The Short QT Syndrome is a recently described new genetic disorder, characterized by abnormally short QT interval, paroxysmal atrial fibrillation and life threatening ventricular arrhythmias. This autosomal dominant syndrome can afflict infants, children, or young adults; often a remarkable family background of cardiac sudden death is elucidated. At electrophysiological study, short atrial and ventricular refractory periods are found, with atrial fibrillation and polymorphic ventricular tachycardia easily induced by programmed electrical stimulation. Gain of function mutations in three genes encoding K+ channels have been identified, explaining the abbreviated repolarization seen in this condition: KCNH2 for Ikr (SQT1), KCNQ1 for Iks (SQT2) and KCNJ2 for Ik1 (SQT3). The currently suggested therapeutic strategy is an ICD implantation, although many concerns exist for asymptomatic patients, especially in pediatric age. Pharmacological treatment is still under evaluation; quinidine has shown to prolong QT and reduce the inducibility of ventricular arrhythmias, but awaits additional confirmatory clinical data.

Original languageEnglish
Pages (from-to)86-95
Number of pages10
JournalIndian Pacing and Electrophysiology Journal
Volume10
Issue number2
Publication statusPublished - Feb 2010

Keywords

  • Channelopathies
  • ICD
  • Short QT syndrome
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Fingerprint

Dive into the research topics of 'Congenital short QT syndrome'. Together they form a unique fingerprint.

Cite this