Abstract
By treatment with methoxide anion on polymeric support (IRA 900), chiral β-oxo or β-sulphonyl-amides 2 bearing an α,β-unsaturated ester gave 3,4-disubstituted pyrrolidin-2-ones 3 as easily separable diastereomeric mixtures in good yield and moderate-to-good stereoselection. The polymeric reagent was also effective in promoting both intermolecular conjugate addition and alkylation reactions. (C) 2000 Elsevier Science Ltd.
Original language | English |
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Pages (from-to) | 8577-8580 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 41 |
Issue number | 44 |
Publication status | Published - Oct 28 2000 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery