Conjugate intra- and intermolecular addition mediated by methoxide anion on polymeric support

C. Fava, R. Galeazzi, E. M. Gonzalez-Rosende, M. Orena

Research output: Contribution to journalArticlepeer-review

Abstract

By treatment with methoxide anion on polymeric support (IRA 900), chiral β-oxo or β-sulphonyl-amides 2 bearing an α,β-unsaturated ester gave 3,4-disubstituted pyrrolidin-2-ones 3 as easily separable diastereomeric mixtures in good yield and moderate-to-good stereoselection. The polymeric reagent was also effective in promoting both intermolecular conjugate addition and alkylation reactions. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)8577-8580
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number44
Publication statusPublished - Oct 28 2000

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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