Conjugate intra- and intermolecular addition mediated by methoxide anion on polymeric support

C. Fava; R. Galeazzi; E. M. Gonzalez-Rosende; M. Orena

Conjugate intra- and intermolecular addition mediated by methoxide anion on polymeric support

C. Fava, R. Galeazzi, E. M. Gonzalez-Rosende, M. Orena

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

By treatment with methoxide anion on polymeric support (IRA 900), chiral β-oxo or β-sulphonyl-amides 2 bearing an α,β-unsaturated ester gave 3,4-disubstituted pyrrolidin-2-ones 3 as easily separable diastereomeric mixtures in good yield and moderate-to-good stereoselection. The polymeric reagent was also effective in promoting both intermolecular conjugate addition and alkylation reactions. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	8577-8580
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	44
Publication status	Published - Oct 28 2000

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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abstract = "By treatment with methoxide anion on polymeric support (IRA 900), chiral β-oxo or β-sulphonyl-amides 2 bearing an α,β-unsaturated ester gave 3,4-disubstituted pyrrolidin-2-ones 3 as easily separable diastereomeric mixtures in good yield and moderate-to-good stereoselection. The polymeric reagent was also effective in promoting both intermolecular conjugate addition and alkylation reactions. (C) 2000 Elsevier Science Ltd.",

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T1 - Conjugate intra- and intermolecular addition mediated by methoxide anion on polymeric support

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AU - Galeazzi, R.

AU - Gonzalez-Rosende, E. M.

AU - Orena, M.

PY - 2000/10/28

Y1 - 2000/10/28

N2 - By treatment with methoxide anion on polymeric support (IRA 900), chiral β-oxo or β-sulphonyl-amides 2 bearing an α,β-unsaturated ester gave 3,4-disubstituted pyrrolidin-2-ones 3 as easily separable diastereomeric mixtures in good yield and moderate-to-good stereoselection. The polymeric reagent was also effective in promoting both intermolecular conjugate addition and alkylation reactions. (C) 2000 Elsevier Science Ltd.

AB - By treatment with methoxide anion on polymeric support (IRA 900), chiral β-oxo or β-sulphonyl-amides 2 bearing an α,β-unsaturated ester gave 3,4-disubstituted pyrrolidin-2-ones 3 as easily separable diastereomeric mixtures in good yield and moderate-to-good stereoselection. The polymeric reagent was also effective in promoting both intermolecular conjugate addition and alkylation reactions. (C) 2000 Elsevier Science Ltd.

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