By treatment with methoxide anion on polymeric support (IRA 900), chiral β-oxo or β-sulphonyl-amides 2 bearing an α,β-unsaturated ester gave 3,4-disubstituted pyrrolidin-2-ones 3 as easily separable diastereomeric mixtures in good yield and moderate-to-good stereoselection. The polymeric reagent was also effective in promoting both intermolecular conjugate addition and alkylation reactions. (C) 2000 Elsevier Science Ltd.
|Number of pages||4|
|Publication status||Published - Oct 28 2000|
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery