Conjugated bilirubin in neonates with glucose-6-phosphate dehydrogenase deficiency

M. Kaplan, F. F. Rubaltelli, C. Hammerman, M. T. Vilei, C. Leiter, A. Abramov, M. Muraca

Research output: Contribution to journalArticlepeer-review

Abstract

We used a system capable of measuring conjugated bilirubin and its monoconjugated and diconjugated fractions in serum to assess bilirubin conjugation in 29 glucose-6-phosphate dehydrogenase (G6PD)-deficient, term, male newborn infants and 35 control subjects; all had serum bilirubin levels ≥256 μmol/L (15 mg/dl). The median value for diconjugated bilirubin was lower in the G6PD-deficient neonates than in control subjects (0.06 (range 0.00 to 1.84) vs 0.21 (range 0.00 to 1.02) pmol/L, p = 0.006). Diglucuronide was undetectable in 11 (38.9%) of the G6PD-deficient infants versus 3 (8.6%) of the control subjects (p = 0.015). These findings imply a partial defect of bilirubin conjugation not previously demonstrated in G6PD-deficient newborn infants.

Original languageEnglish
Pages (from-to)695-697
Number of pages3
JournalJournal of Pediatrics
Volume128
Issue number5 I
DOIs
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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