Abstract
Hydroxytyrosol, a natural polyphenol that can be extracted from olive mill waste waters, was converted into a series of more complex and lipophilic analogues by conjugation with other naturally derived (poly)phenolic fragments. Ether and triazole linkers were employed. A small library of compounds was prepared, stressing step economy and operational simplicity. Some of these substances were proven to have activity equal or superior to that of the parent hydroxytyrosol in radical scavenging assays as well as in cytotoxicity tests against tumour cells.
| Original language | English |
|---|---|
| Pages (from-to) | 6710-6726 |
| Number of pages | 17 |
| Journal | European Journal of Organic Chemistry |
| Volume | 2015 |
| Issue number | 30 |
| DOIs | |
| Publication status | Published - Oct 1 2015 |
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Keywords
- Antioxidants
- Azides
- Nitrogen heterocycles
- Nucleophilic substitution
- Polyphenols
ASJC Scopus subject areas
- Organic Chemistry
- Physical and Theoretical Chemistry
Cite this
Conjugation of Hydroxytyrosol with Other Natural Phenolic Fragments : From Waste to Antioxidants and Antitumour Compounds. / Tassano, Erika; Alama, Angela; Basso, Andrea; Dondo, Giancarlo; Galatini, Andrea; Riva, Renata; Banfi, Luca.
In: European Journal of Organic Chemistry, Vol. 2015, No. 30, 01.10.2015, p. 6710-6726.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Conjugation of Hydroxytyrosol with Other Natural Phenolic Fragments
T2 - From Waste to Antioxidants and Antitumour Compounds
AU - Tassano, Erika
AU - Alama, Angela
AU - Basso, Andrea
AU - Dondo, Giancarlo
AU - Galatini, Andrea
AU - Riva, Renata
AU - Banfi, Luca
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Hydroxytyrosol, a natural polyphenol that can be extracted from olive mill waste waters, was converted into a series of more complex and lipophilic analogues by conjugation with other naturally derived (poly)phenolic fragments. Ether and triazole linkers were employed. A small library of compounds was prepared, stressing step economy and operational simplicity. Some of these substances were proven to have activity equal or superior to that of the parent hydroxytyrosol in radical scavenging assays as well as in cytotoxicity tests against tumour cells.
AB - Hydroxytyrosol, a natural polyphenol that can be extracted from olive mill waste waters, was converted into a series of more complex and lipophilic analogues by conjugation with other naturally derived (poly)phenolic fragments. Ether and triazole linkers were employed. A small library of compounds was prepared, stressing step economy and operational simplicity. Some of these substances were proven to have activity equal or superior to that of the parent hydroxytyrosol in radical scavenging assays as well as in cytotoxicity tests against tumour cells.
KW - Antioxidants
KW - Azides
KW - Nitrogen heterocycles
KW - Nucleophilic substitution
KW - Polyphenols
UR - http://www.scopus.com/inward/record.url?scp=84945452190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84945452190&partnerID=8YFLogxK
U2 - 10.1002/ejoc.201500931
DO - 10.1002/ejoc.201500931
M3 - Article
VL - 2015
SP - 6710
EP - 6726
JO - Annalen der Pharmacie
JF - Annalen der Pharmacie
SN - 0075-4617
IS - 30
ER -