Conjugation of Hydroxytyrosol with Other Natural Phenolic Fragments: From Waste to Antioxidants and Antitumour Compounds

Erika Tassano, Angela Alama, Andrea Basso, Giancarlo Dondo, Andrea Galatini, Renata Riva, Luca Banfi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hydroxytyrosol, a natural polyphenol that can be extracted from olive mill waste waters, was converted into a series of more complex and lipophilic analogues by conjugation with other naturally derived (poly)phenolic fragments. Ether and triazole linkers were employed. A small library of compounds was prepared, stressing step economy and operational simplicity. Some of these substances were proven to have activity equal or superior to that of the parent hydroxytyrosol in radical scavenging assays as well as in cytotoxicity tests against tumour cells.

Original languageEnglish
Pages (from-to)6710-6726
Number of pages17
JournalEuropean Journal of Organic Chemistry
Volume2015
Issue number30
DOIs
Publication statusPublished - Oct 1 2015

Fingerprint

waste water
scavenging
antioxidants
economy
conjugation
ethers
tumors
Antioxidants
fragments
analogs
Triazoles
Scavenging
Polyphenols
Cytotoxicity
Ether
Tumors
Assays
Wastewater
Cells
3,4-dihydroxyphenylethanol

Keywords

  • Antioxidants
  • Azides
  • Nitrogen heterocycles
  • Nucleophilic substitution
  • Polyphenols

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

Conjugation of Hydroxytyrosol with Other Natural Phenolic Fragments : From Waste to Antioxidants and Antitumour Compounds. / Tassano, Erika; Alama, Angela; Basso, Andrea; Dondo, Giancarlo; Galatini, Andrea; Riva, Renata; Banfi, Luca.

In: European Journal of Organic Chemistry, Vol. 2015, No. 30, 01.10.2015, p. 6710-6726.

Research output: Contribution to journalArticle

Tassano, Erika ; Alama, Angela ; Basso, Andrea ; Dondo, Giancarlo ; Galatini, Andrea ; Riva, Renata ; Banfi, Luca. / Conjugation of Hydroxytyrosol with Other Natural Phenolic Fragments : From Waste to Antioxidants and Antitumour Compounds. In: European Journal of Organic Chemistry. 2015 ; Vol. 2015, No. 30. pp. 6710-6726.
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