TY - JOUR
T1 - Conjunctival hyperresponsiveness to ocular histamaine challenge in patients with vernal conjunctivitis
AU - Bonini, Stefano
AU - Bonini, Sergio
AU - Schiavone, Mauro
AU - Centofanti, Marco
AU - Allansmith, Mathea R.
AU - Bucci, Massimo G.
PY - 1992
Y1 - 1992
N2 - We compared the conjunctival responsiveness to histamine diphosphate in patients with vernal conjunctivitis and in healthy control subjects. Fourteen asymptomatic patients with vernal conjunctivitis and 10 healthy volunteers were challenged in one eye with 10 μl of increasing doses (0.01, 0.05, 0.5, and 1 mg/ml in phosphate-buffered saline) of histamine diphosphate. The contralateral eye was challenged with the diluent only. Photographs of each eye were taken for evaluation of conjunctival redness by two masked investigators. Both patients with vernal conjunctivitis and control subjects reacted to histamine with a dose-dependent conjunctival redness 2 to 5 minutes after ocular challenge. Conjunctival redness was more intense in patients with vernal conjunctivitis than in control subjects after ocular challenge with 0.01 and 0.05 mg/ml of histamine diphosphate solution (p
AB - We compared the conjunctival responsiveness to histamine diphosphate in patients with vernal conjunctivitis and in healthy control subjects. Fourteen asymptomatic patients with vernal conjunctivitis and 10 healthy volunteers were challenged in one eye with 10 μl of increasing doses (0.01, 0.05, 0.5, and 1 mg/ml in phosphate-buffered saline) of histamine diphosphate. The contralateral eye was challenged with the diluent only. Photographs of each eye were taken for evaluation of conjunctival redness by two masked investigators. Both patients with vernal conjunctivitis and control subjects reacted to histamine with a dose-dependent conjunctival redness 2 to 5 minutes after ocular challenge. Conjunctival redness was more intense in patients with vernal conjunctivitis than in control subjects after ocular challenge with 0.01 and 0.05 mg/ml of histamine diphosphate solution (p
KW - hyperreactivity
KW - ocular allergy
KW - Vernal conjunctivitis
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U2 - 10.1016/S0091-6749(05)80046-6
DO - 10.1016/S0091-6749(05)80046-6
M3 - Article
C2 - 1730830
AN - SCOPUS:0026580257
VL - 89
SP - 103
EP - 107
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 1 PART 1
ER -