Conjunctival hyperresponsiveness to ocular histamaine challenge in patients with vernal conjunctivitis

Stefano Bonini, Sergio Bonini, Mauro Schiavone, Marco Centofanti, Mathea R. Allansmith, Massimo G. Bucci

Research output: Contribution to journalArticlepeer-review

Abstract

We compared the conjunctival responsiveness to histamine diphosphate in patients with vernal conjunctivitis and in healthy control subjects. Fourteen asymptomatic patients with vernal conjunctivitis and 10 healthy volunteers were challenged in one eye with 10 μl of increasing doses (0.01, 0.05, 0.5, and 1 mg/ml in phosphate-buffered saline) of histamine diphosphate. The contralateral eye was challenged with the diluent only. Photographs of each eye were taken for evaluation of conjunctival redness by two masked investigators. Both patients with vernal conjunctivitis and control subjects reacted to histamine with a dose-dependent conjunctival redness 2 to 5 minutes after ocular challenge. Conjunctival redness was more intense in patients with vernal conjunctivitis than in control subjects after ocular challenge with 0.01 and 0.05 mg/ml of histamine diphosphate solution (p

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalJournal of Allergy and Clinical Immunology
Volume89
Issue number1 PART 1
DOIs
Publication statusPublished - 1992

Keywords

  • hyperreactivity
  • ocular allergy
  • Vernal conjunctivitis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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