Variazioni di fattori del metabolismo fosfo-calcico in funzione della velocita di turnover osseo. Studio epidemiologico sull'osteoporosi (parte seconda)

Translated title of the contribution: Connections between phospho-calcium metabolism and bone turnover. Epidemiologic study on osteoporosis (second part)

M. Maini, E. Brignoli, G. Felicetti, M. Bozzi

Research output: Contribution to journalArticlepeer-review


Background. The recent development of highly accurate and precise osseous mass quantitative evaluation methodology, permits the conduction, in the sphere of osteoporosis, of epidemiologic investigations no longer limited solely to fracture complications, but also based on the definition of osseous mass. Fractures being only complications, possible but not certain, of the advanced stages of the disease, the studies based on their incidence allow one to underestimate the global entity of prevalence and incidence, besides building only a partially useful reference in view of primary and secondary prevention. Methods. The main points of our study are the following: 1) evaluation of the incidence of the primary risk factors for osteoporosis as they appear in the literature, on the bone mass values of examined subjects, utilizing static mineralometric data as a reference standard; 2) study of biohumoral data relative to phospho-calcium metabolism and to sexual function, to show the possibility of their use as early identifying markers of subjects at risk; reference values represented by dynamic mineralometric data. The principal conclusions that emerged in the course of the study are the following. Results. In relation to the use of phospho-calcium metabolic biohumoral and hormonal variables, as a predictive function on the variations of bone turnover, the variables: osteocalcin, alkaline phosphatase, alkaline phosphatase bone isoenzyme, hydroxyprolinuria/creatininuria, have resulted significantly different in the comparison between high and low turnover subjects. The degree of quantitative correlation of such variables with the entity of percentage decrement of bone mass has been modest. The overall value of R-square of the predictive model, besides the variables mentioned the value of bone mass at 1°control visit, was 0.38 (osteocalcin: 0.27; osteocalcin + hydroxyprolinuria/creatininuria: 0.33; preceding variables + bone mass at 1st control: 0.36; preceding variables + alkaline phosphatase: 0.37; preceding variables + alkaline phosphatase bone isoenzyme: 0.38). Conclusions. The single value osteocalcin may furnish indications on the future variations of bone turnover and consequently on the early identification of the subjects at risk for osteoporosis at high turnover; the addition of the other variables indicated in our predictive model allows an increase of the possibilities of individualizing of these subjects.

Translated title of the contributionConnections between phospho-calcium metabolism and bone turnover. Epidemiologic study on osteoporosis (second part)
Original languageItalian
Pages (from-to)565-576
Number of pages12
JournalMinerva Medica
Issue number12
Publication statusPublished - Dec 1996

ASJC Scopus subject areas

  • Medicine(all)


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