Correlazioni fra fattori di rischio e massa ossea in periodo pre- e post-menopausale. Studio epidemiologico sull'osteoporosi (Parte prima)

Translated title of the contribution: Connections between risk factors and bone mass. Epidemiologic study on osteoporosis (First part)

M. Maini, E. Brignoli, G. Felicetti, M. Bozzi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The recent development of highly accurate and precise osseous mass quantitative evaluation methodology, permits the conduction, in the sphere of osteoporosis, of epidemiologic investigations no longer limited solely to fracture complications but also based on the definition of osseous mass. Fractures being only complications, possible but not certain, of the advanced stages of the diseases, the studies based on their incidence allow one to underestimate the global entity of prevalence and incidence, besides building only a partially useful reference in view of primary and secondary prevention. The main points of our study are the following: 1) evaluation of the incidence of the primary risk factors for osteoporosis as they appear in the literature, on the bone mass values of examined subjects, utilizing static mineralometric data as a reference standard; 2) study of biohumoral data relative to phospho-calcium metabolism and to sexual function, to show the possibility of their use as early identifying markers of subjects at risk; references values represented by dynamic mineralometric data. The principal conclusions that emerged in the course of the study are the following. In regard to the evaluation of the principal risk factors, they prove to be correlated to the osseous mass values registered at the first control: physical activity (highly positive action). Favorable levels of correlation were also discovered for the variables of increased body weight (positive action) and increased age (negative action). In multivariate analysis, the R-square value (index of the variation fraction of osseous mass values due to the risk factors) has reached a total value of 0.65 (physical activity: 0.46; phiysical activity+dietary calcium: 0.55; history+increased age: 0.58: history+smoking: 0.62; history+increased weight: 0.64; history+pre- or post-menopausal: (0.65). Such analysis furnishes useful indications on the modalities to employ in the anamnestic framing of the patients at risk for osteoporosis, and on the importance attributable to single risk factors.

Original languageItalian
Pages (from-to)385-399
Number of pages15
JournalMinerva Medica
Volume87
Issue number9
Publication statusPublished - Sep 1996

Fingerprint

Osteoporosis
Epidemiologic Studies
History
Bone and Bones
Incidence
Exercise
Dietary Calcium
Primary Prevention
Secondary Prevention
Reference Values
Multivariate Analysis
Smoking
Body Weight
Calcium
Weights and Measures

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Correlazioni fra fattori di rischio e massa ossea in periodo pre- e post-menopausale. Studio epidemiologico sull'osteoporosi (Parte prima). / Maini, M.; Brignoli, E.; Felicetti, G.; Bozzi, M.

In: Minerva Medica, Vol. 87, No. 9, 09.1996, p. 385-399.

Research output: Contribution to journalArticle

@article{817228046c6f40e49936e044adf8e1b0,
title = "Correlazioni fra fattori di rischio e massa ossea in periodo pre- e post-menopausale. Studio epidemiologico sull'osteoporosi (Parte prima)",
abstract = "The recent development of highly accurate and precise osseous mass quantitative evaluation methodology, permits the conduction, in the sphere of osteoporosis, of epidemiologic investigations no longer limited solely to fracture complications but also based on the definition of osseous mass. Fractures being only complications, possible but not certain, of the advanced stages of the diseases, the studies based on their incidence allow one to underestimate the global entity of prevalence and incidence, besides building only a partially useful reference in view of primary and secondary prevention. The main points of our study are the following: 1) evaluation of the incidence of the primary risk factors for osteoporosis as they appear in the literature, on the bone mass values of examined subjects, utilizing static mineralometric data as a reference standard; 2) study of biohumoral data relative to phospho-calcium metabolism and to sexual function, to show the possibility of their use as early identifying markers of subjects at risk; references values represented by dynamic mineralometric data. The principal conclusions that emerged in the course of the study are the following. In regard to the evaluation of the principal risk factors, they prove to be correlated to the osseous mass values registered at the first control: physical activity (highly positive action). Favorable levels of correlation were also discovered for the variables of increased body weight (positive action) and increased age (negative action). In multivariate analysis, the R-square value (index of the variation fraction of osseous mass values due to the risk factors) has reached a total value of 0.65 (physical activity: 0.46; phiysical activity+dietary calcium: 0.55; history+increased age: 0.58: history+smoking: 0.62; history+increased weight: 0.64; history+pre- or post-menopausal: (0.65). Such analysis furnishes useful indications on the modalities to employ in the anamnestic framing of the patients at risk for osteoporosis, and on the importance attributable to single risk factors.",
keywords = "bone mass, epidemiology, osteoporosis, risk factors",
author = "M. Maini and E. Brignoli and G. Felicetti and M. Bozzi",
year = "1996",
month = "9",
language = "Italian",
volume = "87",
pages = "385--399",
journal = "Minerva Medicolegale e Archivio di Antropologia Criminale",
issn = "0026-4806",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "9",

}

TY - JOUR

T1 - Correlazioni fra fattori di rischio e massa ossea in periodo pre- e post-menopausale. Studio epidemiologico sull'osteoporosi (Parte prima)

AU - Maini, M.

AU - Brignoli, E.

AU - Felicetti, G.

AU - Bozzi, M.

PY - 1996/9

Y1 - 1996/9

N2 - The recent development of highly accurate and precise osseous mass quantitative evaluation methodology, permits the conduction, in the sphere of osteoporosis, of epidemiologic investigations no longer limited solely to fracture complications but also based on the definition of osseous mass. Fractures being only complications, possible but not certain, of the advanced stages of the diseases, the studies based on their incidence allow one to underestimate the global entity of prevalence and incidence, besides building only a partially useful reference in view of primary and secondary prevention. The main points of our study are the following: 1) evaluation of the incidence of the primary risk factors for osteoporosis as they appear in the literature, on the bone mass values of examined subjects, utilizing static mineralometric data as a reference standard; 2) study of biohumoral data relative to phospho-calcium metabolism and to sexual function, to show the possibility of their use as early identifying markers of subjects at risk; references values represented by dynamic mineralometric data. The principal conclusions that emerged in the course of the study are the following. In regard to the evaluation of the principal risk factors, they prove to be correlated to the osseous mass values registered at the first control: physical activity (highly positive action). Favorable levels of correlation were also discovered for the variables of increased body weight (positive action) and increased age (negative action). In multivariate analysis, the R-square value (index of the variation fraction of osseous mass values due to the risk factors) has reached a total value of 0.65 (physical activity: 0.46; phiysical activity+dietary calcium: 0.55; history+increased age: 0.58: history+smoking: 0.62; history+increased weight: 0.64; history+pre- or post-menopausal: (0.65). Such analysis furnishes useful indications on the modalities to employ in the anamnestic framing of the patients at risk for osteoporosis, and on the importance attributable to single risk factors.

AB - The recent development of highly accurate and precise osseous mass quantitative evaluation methodology, permits the conduction, in the sphere of osteoporosis, of epidemiologic investigations no longer limited solely to fracture complications but also based on the definition of osseous mass. Fractures being only complications, possible but not certain, of the advanced stages of the diseases, the studies based on their incidence allow one to underestimate the global entity of prevalence and incidence, besides building only a partially useful reference in view of primary and secondary prevention. The main points of our study are the following: 1) evaluation of the incidence of the primary risk factors for osteoporosis as they appear in the literature, on the bone mass values of examined subjects, utilizing static mineralometric data as a reference standard; 2) study of biohumoral data relative to phospho-calcium metabolism and to sexual function, to show the possibility of their use as early identifying markers of subjects at risk; references values represented by dynamic mineralometric data. The principal conclusions that emerged in the course of the study are the following. In regard to the evaluation of the principal risk factors, they prove to be correlated to the osseous mass values registered at the first control: physical activity (highly positive action). Favorable levels of correlation were also discovered for the variables of increased body weight (positive action) and increased age (negative action). In multivariate analysis, the R-square value (index of the variation fraction of osseous mass values due to the risk factors) has reached a total value of 0.65 (physical activity: 0.46; phiysical activity+dietary calcium: 0.55; history+increased age: 0.58: history+smoking: 0.62; history+increased weight: 0.64; history+pre- or post-menopausal: (0.65). Such analysis furnishes useful indications on the modalities to employ in the anamnestic framing of the patients at risk for osteoporosis, and on the importance attributable to single risk factors.

KW - bone mass

KW - epidemiology

KW - osteoporosis

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=0029818301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029818301&partnerID=8YFLogxK

M3 - Articolo

VL - 87

SP - 385

EP - 399

JO - Minerva Medicolegale e Archivio di Antropologia Criminale

JF - Minerva Medicolegale e Archivio di Antropologia Criminale

SN - 0026-4806

IS - 9

ER -