Abstract
In this multicenter study, we performed a tractography-based parcellation of the thalamus and its white matter connections to investigate the relationship between thalamic connectivity abnormalities and cognitive impairment in multiple sclerosis (MS). Dual-echo, morphological and diffusion tensor (DT) magnetic resonance imaging (MRI) scans were collected from 52 relapsing-remitting MS patients and 57 healthy controls from six European centers. Patients underwent an extensive neuropsychological assessment. Thalamic connectivity defined regions (CDRs) were segmented based on their cortical connectivity using diffusion tractography-based parcellation. Between-group differences of CDRs and cortico-thalamic tracts DT MRI indices were assessed. A vertex analysis of thalamic shape was also performed. A random forest analysis was run to identify the best imaging predictor of global cognitive impairment and deficits of specific cognitive domains. Twenty-two (43%) MS patients were cognitively impaired (CI). Compared to cognitively preserved, CI MS patients had increased fractional anisotropy of frontal, motor, postcentral and occipital connected CDRs (0.002
| Original language | English |
|---|---|
| Pages (from-to) | 2809-2825 |
| Number of pages | 17 |
| Journal | Human Brain Mapping |
| Volume | 36 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2015 |
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Keywords
- Cognitive impairment
- DT MRI
- Gray matter
- Multiple sclerosis
- Thalamus
- White matter
ASJC Scopus subject areas
- Clinical Neurology
- Anatomy
- Neurology
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Connectivity-based parcellation of the thalamus in multiple sclerosis and its implications for cognitive impairment : A multicenter study. / Bisecco, Alvino; Rocca, Maria A.; Pagani, Elisabetta; Mancini, Laura; Enzinger, Christian; Gallo, Antonio; Vrenken, Hugo; Stromillo, Maria Laura; Copetti, Massimiliano; Thomas, David L.; Fazekas, Franz; Tedeschi, Gioacchino; Barkhof, Frederik; Stefano, Nicola De; Filippi, Massimo.
In: Human Brain Mapping, Vol. 36, No. 7, 01.07.2015, p. 2809-2825.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Connectivity-based parcellation of the thalamus in multiple sclerosis and its implications for cognitive impairment
T2 - A multicenter study
AU - Bisecco, Alvino
AU - Rocca, Maria A.
AU - Pagani, Elisabetta
AU - Mancini, Laura
AU - Enzinger, Christian
AU - Gallo, Antonio
AU - Vrenken, Hugo
AU - Stromillo, Maria Laura
AU - Copetti, Massimiliano
AU - Thomas, David L.
AU - Fazekas, Franz
AU - Tedeschi, Gioacchino
AU - Barkhof, Frederik
AU - Stefano, Nicola De
AU - Filippi, Massimo
PY - 2015/7/1
Y1 - 2015/7/1
N2 - In this multicenter study, we performed a tractography-based parcellation of the thalamus and its white matter connections to investigate the relationship between thalamic connectivity abnormalities and cognitive impairment in multiple sclerosis (MS). Dual-echo, morphological and diffusion tensor (DT) magnetic resonance imaging (MRI) scans were collected from 52 relapsing-remitting MS patients and 57 healthy controls from six European centers. Patients underwent an extensive neuropsychological assessment. Thalamic connectivity defined regions (CDRs) were segmented based on their cortical connectivity using diffusion tractography-based parcellation. Between-group differences of CDRs and cortico-thalamic tracts DT MRI indices were assessed. A vertex analysis of thalamic shape was also performed. A random forest analysis was run to identify the best imaging predictor of global cognitive impairment and deficits of specific cognitive domains. Twenty-two (43%) MS patients were cognitively impaired (CI). Compared to cognitively preserved, CI MS patients had increased fractional anisotropy of frontal, motor, postcentral and occipital connected CDRs (0.002
AB - In this multicenter study, we performed a tractography-based parcellation of the thalamus and its white matter connections to investigate the relationship between thalamic connectivity abnormalities and cognitive impairment in multiple sclerosis (MS). Dual-echo, morphological and diffusion tensor (DT) magnetic resonance imaging (MRI) scans were collected from 52 relapsing-remitting MS patients and 57 healthy controls from six European centers. Patients underwent an extensive neuropsychological assessment. Thalamic connectivity defined regions (CDRs) were segmented based on their cortical connectivity using diffusion tractography-based parcellation. Between-group differences of CDRs and cortico-thalamic tracts DT MRI indices were assessed. A vertex analysis of thalamic shape was also performed. A random forest analysis was run to identify the best imaging predictor of global cognitive impairment and deficits of specific cognitive domains. Twenty-two (43%) MS patients were cognitively impaired (CI). Compared to cognitively preserved, CI MS patients had increased fractional anisotropy of frontal, motor, postcentral and occipital connected CDRs (0.002
KW - Cognitive impairment
KW - DT MRI
KW - Gray matter
KW - Multiple sclerosis
KW - Thalamus
KW - White matter
UR - http://www.scopus.com/inward/record.url?scp=84931955900&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931955900&partnerID=8YFLogxK
U2 - 10.1002/hbm.22809
DO - 10.1002/hbm.22809
M3 - Article
C2 - 25873194
AN - SCOPUS:84931955900
VL - 36
SP - 2809
EP - 2825
JO - Human Brain Mapping
JF - Human Brain Mapping
SN - 1065-9471
IS - 7
ER -