Conotruncal anomalies in prenatal life

D. Paladini, M. Rustico, T. Todros, S. Palmieri, P. Gaglioti, A. Benettoni, M. G. Russo, E. Chiappa, G. D'Ottavio

Research output: Contribution to journalArticlepeer-review


This retrospective multicenter study represents an analysis of the intrauterine determinants of the prognosis for conotruncal anomalies. Data regarding reason for referral, presence of chromosomal or extracardiac anomalies, pregnancy and surgical outcome were recorded in 67 cases of conotruncal anomalies from three Italian referral units. Chromosomal aberrations affected 11 of the 60 (18.3%) fetuses in which a karyotype was available. Extracardiac malformations were present in 25167 cases (37.3%). No chromosomal anomalies were present in fetuses with complete or corrected transposition of the great arteries. However, tetralogy of Fallot and double-outlet right ventricle were associated with chromosomal anomalies in 22% and 38% of cases, respectively, and with extracardiac anomalies in 45% and 46% of cases, respectively. Only 20 of the 67 (31%) cardiac malformations were associated with an abnormal four-chamber view. There were 28 (41.7%) terminations of pregnancy, six (8.9%) intrauterine deaths and 16 (23.8%) neonatal deaths. Seventeen neonates (25.3%) are currently alive, and 15 of these have undergone reparative surgery. The prognosis of conotruncal anomalies is poorer when the condition is diagnosed in utero. This is mainly due to the frequent association with chromosomal and/or extracardiac anomalies, often leading to intrauterine or early neonatal death.

Original languageEnglish
Pages (from-to)241-246
Number of pages6
JournalUltrasound in Obstetrics and Gynecology
Issue number4
Publication statusPublished - 1996


  • Chromosome
  • Echocardiography
  • Fetus
  • Heart disease
  • Prenatal diagnosis
  • Ultrasound

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Radiology Nuclear Medicine and imaging
  • Reproductive Medicine
  • Acoustics and Ultrasonics
  • Radiological and Ultrasound Technology


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