TY - JOUR
T1 - Consensus document on controversial issues in the diagnosis and treatment of prosthetic joint infections
AU - Leone, Sebastiano
AU - Borrè, Silvio
AU - Monforte, Antonella d Arminio
AU - Mordente, Gennaro
AU - Petrosillo, Nicola
AU - Signore, Alberto
AU - Venditti, Mario
AU - Viale, Pierluigi
AU - Nicastri, Emanuele
AU - Lauria, Francesco N.
AU - Carosi, Giampiero
AU - Moroni, Mauro
AU - Ippolito, Giuseppe
PY - 2010/10
Y1 - 2010/10
N2 - Background: Joint replacement surgery has been on the increase in recent decades and prosthesis infection remains the most critical complication. Many aspects of the primary prevention and clinical management of such prosthesis infections still need to be clarified. Controversial issues: The aim of this GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) working group - a panel of multidisciplinary experts - was to define recommendations for the following controversial issues: (1) Is a conservative surgical approach for the management of prosthetic joint infections effective? (2) Is the one-stage or the two-stage revision for the management of prosthetic joint infections more effective? (3) What is the most effective treatment for the management of prosthetic joint infections due to methicillin-resistant staphylococci? Results are presented and discussed in detail. Methods: A systematic literature search using the MEDLINE database for the period 1988 to 2008 of randomized controlled trials and/or non-randomized studies was performed. A matrix was created to extract evidence from original studies using the CONSORT method to evaluate randomized clinical trials and the Newcastle-Ottawa Quality Assessment Scale for case-control studies, longitudinal cohorts, and retrospective studies. The GRADE method for grading quality of evidence and strength of recommendation was applied.
AB - Background: Joint replacement surgery has been on the increase in recent decades and prosthesis infection remains the most critical complication. Many aspects of the primary prevention and clinical management of such prosthesis infections still need to be clarified. Controversial issues: The aim of this GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) working group - a panel of multidisciplinary experts - was to define recommendations for the following controversial issues: (1) Is a conservative surgical approach for the management of prosthetic joint infections effective? (2) Is the one-stage or the two-stage revision for the management of prosthetic joint infections more effective? (3) What is the most effective treatment for the management of prosthetic joint infections due to methicillin-resistant staphylococci? Results are presented and discussed in detail. Methods: A systematic literature search using the MEDLINE database for the period 1988 to 2008 of randomized controlled trials and/or non-randomized studies was performed. A matrix was created to extract evidence from original studies using the CONSORT method to evaluate randomized clinical trials and the Newcastle-Ottawa Quality Assessment Scale for case-control studies, longitudinal cohorts, and retrospective studies. The GRADE method for grading quality of evidence and strength of recommendation was applied.
KW - Conservative surgical approach
KW - Methicillin-resistant staphylococci
KW - One-stage approach
KW - Prosthetic joint infections
KW - Two-stage approach
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U2 - 10.1016/j.ijid.2010.05.005
DO - 10.1016/j.ijid.2010.05.005
M3 - Article
C2 - 20843721
AN - SCOPUS:78149279830
VL - 14
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
SN - 1201-9712
IS - SUPPL. 4
ER -