Consensus document on controversial issues in the diagnosis and treatment of prosthetic joint infections

Sebastiano Leone, Silvio Borrè, Antonella d Arminio Monforte, Gennaro Mordente, Nicola Petrosillo, Alberto Signore, Mario Venditti, Pierluigi Viale, Emanuele Nicastri, Francesco N. Lauria, Giampiero Carosi, Mauro Moroni, Giuseppe Ippolito

Research output: Contribution to journalArticle

Abstract

Background: Joint replacement surgery has been on the increase in recent decades and prosthesis infection remains the most critical complication. Many aspects of the primary prevention and clinical management of such prosthesis infections still need to be clarified. Controversial issues: The aim of this GISIG (Gruppo Italiano di Studio sulle Infezioni Gravi) working group - a panel of multidisciplinary experts - was to define recommendations for the following controversial issues: (1) Is a conservative surgical approach for the management of prosthetic joint infections effective? (2) Is the one-stage or the two-stage revision for the management of prosthetic joint infections more effective? (3) What is the most effective treatment for the management of prosthetic joint infections due to methicillin-resistant staphylococci? Results are presented and discussed in detail. Methods: A systematic literature search using the MEDLINE database for the period 1988 to 2008 of randomized controlled trials and/or non-randomized studies was performed. A matrix was created to extract evidence from original studies using the CONSORT method to evaluate randomized clinical trials and the Newcastle-Ottawa Quality Assessment Scale for case-control studies, longitudinal cohorts, and retrospective studies. The GRADE method for grading quality of evidence and strength of recommendation was applied.

Original languageEnglish
JournalInternational Journal of Infectious Diseases
Volume14
Issue numberSUPPL. 4
DOIs
Publication statusPublished - Oct 2010

Keywords

  • Conservative surgical approach
  • Methicillin-resistant staphylococci
  • One-stage approach
  • Prosthetic joint infections
  • Two-stage approach

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Leone, S., Borrè, S., Monforte, A. D. A., Mordente, G., Petrosillo, N., Signore, A., Venditti, M., Viale, P., Nicastri, E., Lauria, F. N., Carosi, G., Moroni, M., & Ippolito, G. (2010). Consensus document on controversial issues in the diagnosis and treatment of prosthetic joint infections. International Journal of Infectious Diseases, 14(SUPPL. 4). https://doi.org/10.1016/j.ijid.2010.05.005