Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity

Emilia Cirillo, Giuliana Giardino, Silvia Ricci, Viviana Moschese, Vassilios Lougaris, Francesca Conti, Chiara Azzari, Federica Barzaghi, Clementina Canessa, Baldassarre Martire, Raffaele Badolato, Laura Dotta, Annarosa Soresina, Caterina Cancrini, Andrea Finocchi, Davide Montin, Roberta Romano, Donato Amodio, Francesca Ferrua, Alberto TommasiniLucia Augusta Baselli, Rosa Maria Dellepiane, Agata Polizzi, Luciana Chessa, Antonio Marzollo, Maria Pia Cicalese, Maria Caterina Putti, Andrea Pession, Alessandro Aiuti, Franco Locatelli, Alessandro Plebani, Claudio Pignata

Research output: Contribution to journalArticlepeer-review

Abstract

Medical advances have dramatically improved the long-term prognosis of children and adolescents with inborn errors of immunity (IEIs). Transfer of the medical care of individuals with pediatric IEIs to adult facilities is also a complex task because of the large number of distinct disorders, which requires involvement of patients and both pediatric and adult care providers. To date, there is no consensus on the optimal pathway of the transitional care process and no specific data are available in the literature regarding patients with IEIs. We aimed to develop a consensus statement on the transition process to adult health care services for patients with IEIs. Physicians from major Italian Primary Immunodeficiency Network centers formulated and answered questions after examining the currently published literature on the transition from childhood to adulthood. The authors voted on each recommendation. The most frequent IEIs sharing common main clinical problems requiring full attention during the transitional phase were categorized into different groups of clinically related disorders. For each group of clinically related disorders, physicians from major Italian Primary Immunodeficiency Network institutions focused on selected clinical issues representing the clinical hallmark during early adulthood.

Original languageEnglish
Pages (from-to)967-983
JournalJournal of Allergy and Clinical Immunology
Volume146
Issue number5
DOIs
Publication statusPublished - 2020

Keywords

  • combined immunodeficiency
  • DiGeorge syndrome
  • DNA repair syndromes
  • humoral immune defects
  • inborn errors of immunity
  • innate immune defects
  • Italian Network of Primary Immunodeficiencies
  • primary immunodeficiency
  • Transitional care

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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