Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity: Journal of Allergy and Clinical Immunology

E. Cirillo, G. Giardino, S. Ricci, V. Moschese, V. Lougaris, F. Conti, C. Azzari, F. Barzaghi, C. Canessa, B. Martire, R. Badolato, L. Dotta, A. Soresina, C. Cancrini, A. Finocchi, D. Montin, R. Romano, D. Amodio, F. Ferrua, A. TommasiniL.A. Baselli, R.M. Dellepiane, A. Polizzi, L. Chessa, A. Marzollo, M.P. Cicalese, M.C. Putti, A. Pession, A. Aiuti, F. Locatelli, A. Plebani, C. Pignata

Research output: Contribution to journalArticlepeer-review

Abstract

Medical advances have dramatically improved the long-term prognosis of children and adolescents with inborn errors of immunity (IEIs). Transfer of the medical care of individuals with pediatric IEIs to adult facilities is also a complex task because of the large number of distinct disorders, which requires involvement of patients and both pediatric and adult care providers. To date, there is no consensus on the optimal pathway of the transitional care process and no specific data are available in the literature regarding patients with IEIs. We aimed to develop a consensus statement on the transition process to adult health care services for patients with IEIs. Physicians from major Italian Primary Immunodeficiency Network centers formulated and answered questions after examining the currently published literature on the transition from childhood to adulthood. The authors voted on each recommendation. The most frequent IEIs sharing common main clinical problems requiring full attention during the transitional phase were categorized into different groups of clinically related disorders. For each group of clinically related disorders, physicians from major Italian Primary Immunodeficiency Network institutions focused on selected clinical issues representing the clinical hallmark during early adulthood. © 2020 American Academy of Allergy, Asthma & Immunology
Original languageEnglish
Pages (from-to)967-983
Number of pages17
JournalJ. Allergy Clin. Immunol.
Volume146
Issue number5
DOIs
Publication statusPublished - 2020

Keywords

  • combined immunodeficiency
  • DiGeorge syndrome
  • DNA repair syndromes
  • humoral immune defects
  • inborn errors of immunity
  • innate immune defects
  • Italian Network of Primary Immunodeficiencies
  • primary immunodeficiency
  • Transitional care
  • Article
  • cancer susceptibility
  • child
  • common variable immunodeficiency
  • consensus development
  • DNA repair
  • gene therapy
  • genetic counseling
  • health service
  • hematopoietic stem cell transplantation
  • human
  • humoral immune deficiency
  • immunopathology
  • innate immunity
  • medical decision making
  • medical society
  • phenotype
  • priority journal
  • stress management
  • transition to adult care

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