Consensus on precision medicine for metastatic cancers: A report from the MAP conference

C. Swanton, J. C. Soria, A. Bardelli, A. Biankin, C. Caldas, S. Chandarlapaty, L. de Koning, C. Dive, J. Feunteun, S. Y. Leung, R. Marais, E. R. Mardis, N. McGranahan, G. Middleton, S. A. Quezada, J. Rodón, N. Rosenfeld, C. Sotiriou, Fabrice André

Research output: Contribution to journalArticlepeer-review

Abstract

Recent advances in biotechnologies have led to the development of multiplex genomic and proteomic analyses for clinical use. Nevertheless, guidelines are currently lacking to determine which molecular assays should be implemented in metastatic cancers. The first MAP conference was dedicated to exploring the use of genomics to better select therapies in the treatment of metastatic cancers. Sixteen consensus items were covered. There was a consensus that new technologies like next-generation sequencing of tumors and ddPCR on circulating free DNA have convincing analytical validity. Further work needs to be undertaken to establish the clinical utility of liquid biopsies and the added clinical value of expanding from individual gene tests into large gene panels. Experts agreed that standardized bioinformatics methods for biological interpretation of genomic data are needed and that precision medicine trials should be stratified based on the level of evidence available for the genomic alterations identified.

Original languageEnglish
Pages (from-to)1443-1448
Number of pages6
JournalAnnals of Oncology
Volume27
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • Biomarkers
  • Consensus
  • Precision medicine

ASJC Scopus subject areas

  • Hematology
  • Oncology

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