TY - JOUR
T1 - Consensus paper
T2 - Probing homeostatic plasticity of human cortex with non-invasive transcranial brain stimulation
AU - Karabanov, Anke
AU - Ziemann, Ulf
AU - Hamada, Masashi
AU - George, Mark S.
AU - Quartarone, Angelo
AU - Classen, Joseph
AU - Massimini, Marcello
AU - Rothwell, John
AU - Siebner, Hartwig Roman
PY - 2015
Y1 - 2015
N2 - Homeostatic plasticity is thought to stabilize neural activity around a set point within a physiologically reasonable dynamic range. Over the last ten years, a wide range of non-invasive transcranial brain stimulation (NTBS) techniques have been used to probe homeostatic control of cortical plasticity in the intact human brain. Here, we review different NTBS approaches to study homeostatic plasticity on a systems level and relate the findings to both, physiological evidence from in vitro studies and to a theoretical framework of homeostatic function. We highlight differences between homeostatic and other non-homeostatic forms of plasticity and we examine the contribution of sleep in restoring synaptic homeostasis. Finally, we discuss the growing number of studies showing that abnormal homeostatic plasticity may be associated to a range of neuropsychiatric diseases.
AB - Homeostatic plasticity is thought to stabilize neural activity around a set point within a physiologically reasonable dynamic range. Over the last ten years, a wide range of non-invasive transcranial brain stimulation (NTBS) techniques have been used to probe homeostatic control of cortical plasticity in the intact human brain. Here, we review different NTBS approaches to study homeostatic plasticity on a systems level and relate the findings to both, physiological evidence from in vitro studies and to a theoretical framework of homeostatic function. We highlight differences between homeostatic and other non-homeostatic forms of plasticity and we examine the contribution of sleep in restoring synaptic homeostasis. Finally, we discuss the growing number of studies showing that abnormal homeostatic plasticity may be associated to a range of neuropsychiatric diseases.
KW - Homeostatic plasticity
KW - Long-term inhibition
KW - Long-term potentiation
KW - Metaplasticity
KW - Non-invasive transcranial brain stimulation
KW - Synaptic homeostasis hypothesis
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U2 - 10.1016/j.brs.2015.01.404
DO - 10.1016/j.brs.2015.01.404
M3 - Article
C2 - 26050599
AN - SCOPUS:84942848963
VL - 8
SP - 442
EP - 454
JO - Brain Stimulation
JF - Brain Stimulation
SN - 1935-861X
IS - 3
ER -