Consensus paper: Probing homeostatic plasticity of human cortex with non-invasive transcranial brain stimulation

Anke Karabanov, Ulf Ziemann, Masashi Hamada, Mark S. George, Angelo Quartarone, Joseph Classen, Marcello Massimini, John Rothwell, Hartwig Roman Siebner

Research output: Contribution to journalArticlepeer-review

Abstract

Homeostatic plasticity is thought to stabilize neural activity around a set point within a physiologically reasonable dynamic range. Over the last ten years, a wide range of non-invasive transcranial brain stimulation (NTBS) techniques have been used to probe homeostatic control of cortical plasticity in the intact human brain. Here, we review different NTBS approaches to study homeostatic plasticity on a systems level and relate the findings to both, physiological evidence from in vitro studies and to a theoretical framework of homeostatic function. We highlight differences between homeostatic and other non-homeostatic forms of plasticity and we examine the contribution of sleep in restoring synaptic homeostasis. Finally, we discuss the growing number of studies showing that abnormal homeostatic plasticity may be associated to a range of neuropsychiatric diseases.

Original languageEnglish
Pages (from-to)442-454
Number of pages13
JournalBrain Stimulation
Volume8
Issue number3
DOIs
Publication statusPublished - 2015

Keywords

  • Homeostatic plasticity
  • Long-term inhibition
  • Long-term potentiation
  • Metaplasticity
  • Non-invasive transcranial brain stimulation
  • Synaptic homeostasis hypothesis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Biophysics
  • Medicine(all)

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