Consensus protocol for EEG and amplitude-integrated EEG assessment and monitoring in neonates

INNESCO Group, Robertino Dilena, Federico Raviglione, Gaetano Cantalupo, Duccio M. Cordelli, Paola De Liso, Matteo Di Capua, Raffaele Falsaperla, Fabrizio Ferrari, Monica Fumagalli, Silvia Lori, Agnese Suppiej, Laura Tadini, Bernardo Dalla Bernardina, Massimo Mastrangelo, Francesco Pisani

Research output: Contribution to journalReview articlepeer-review


The aim of this work is to establish inclusive guidelines on electroencephalography (EEG) applicable to all neonatal intensive care units (NICUs). Guidelines on ideal EEG monitoring for neonates are available, but there are significant barriers to their implementation in many centres around the world. These include barriers due to limited resources regarding the availability of equipment and technical and interpretive round-the-clock personnel. On the other hand, despite its limitations, amplitude-integrated EEG (aEEG) (previously called Cerebral Function Monitor [CFM]) is a common alternative used in NICUs. The Italian Neonatal Seizure Collaborative Network (INNESCO), working with all national scientific societies interested in the field of neonatal clinical neurophysiology, performed a systematic literature review and promoted interdisciplinary discussions among experts (neonatologists, paediatric neurologists, neurophysiologists, technicians) between 2017 and 2020 with the aim of elaborating shared recommendations. A consensus statement on videoEEG (vEEG) and aEEG for the principal neonatal indications was established. The authors propose a flexible frame of recommendations based on the complementary use of vEEG and aEEG applicable to the various neonatal units with different levels of complexity according to local resources and specific patient features. Suggestions for promoting cooperation between neonatologists, paediatric neurologists, and neurophysiologists, organisational restructuring, and teleneurophysiology implementation are provided.

Original languageEnglish
Pages (from-to)886-903
Number of pages18
JournalClinical Neurophysiology
Issue number4
Publication statusPublished - Apr 2021


  • Electroencephalography
  • Guideline
  • Hypoxic-ischemic encephalopathy
  • Newborn
  • Review
  • Seizures

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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