Consensus statement from 2nd International Conference on Controversies in Vitamin D

A. Giustina, R. A. Adler, N. Binkley, J. Bollerslev, R. Bouillon, B. Dawson-Hughes, P. R. Ebeling, D. Feldman, A. M. Formenti, M. Lazaretti-Castro, C. Marcocci, R. Rizzoli, C. T. Sempos, J. P. Bilezikian

Research output: Contribution to journalArticlepeer-review


The 2nd International Conference on Controversies in Vitamin D was held in Monteriggioni (Siena), Italy, September 11-14, 2018. The aim of this meeting was to address ongoing controversies and timely topics in vitamin D research, to review available data related to these topics and controversies, to promote discussion to help resolve lingering issues and ultimately to suggest a research agenda to clarify areas of uncertainty. Several issues from the first conference, held in 2017, were revisited, such as assays used to determine serum 25-hydroxyvitamin D [25(OH)D] concentration, which remains a critical and controversial issue for defining vitamin D status. Definitions of vitamin D nutritional status (i.e. sufficiency, insufficiency and deficiency) were also revisited. New areas were reviewed, including vitamin D threshold values and how they should be defined in the context of specific diseases, sources of vitamin D and risk factors associated with vitamin D deficiency. Non-skeletal aspects related to vitamin D were also discussed, including the reproductive system, neurology, chronic kidney disease and falls. The therapeutic role of vitamin D and findings from recent clinical trials were also addressed. The topics were considered by 3 focus groups and divided into three main areas: 1) “Laboratory”: assays and threshold values to define vitamin D status; 2) “Clinical”: sources of vitamin D and risk factors and role of vitamin D in non-skeletal disease and 3) “Therapeutics”: controversial issues on observational studies and recent randomized controlled trials. In this report, we present a summary of our findings.

Original languageEnglish
Pages (from-to)89-116
Number of pages28
JournalReviews in Endocrine and Metabolic Disorders
Issue number1
Publication statusPublished - Mar 1 2020


  • Extra-skeletal effects
  • Food
  • Fractures
  • Osteoporosis
  • Skin
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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