Abstract
The most recent analysis of the results of three major trials on breast conservation carried out at the Milan Cancer Institute between 1973 and 1988 showed that breast conservation consisting of a wide breast resection (quadrantectomy) plus radiotherapy is a safe procedure, and that there are no differences in long-term survival (up to 19 years) compared with women who have undergone Halsted's mastectomy. The studies also showed that reducing the extent of surgery from quadrantectomy to lumpectomy increases the risk of local recurrence by nearly three times, as does withdrawing radiotherapy. However, in women older than 55 years, quadrantectomy alone (without radiotherapy) may yield good results. Among the risk factors for local recurrence, a young age and the presence of an extensive intraductal component are the most significant.
| Original language | English |
|---|---|
| Pages (from-to) | 70-75 |
| Number of pages | 6 |
| Journal | World Journal of Surgery |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1994 |
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ASJC Scopus subject areas
- Surgery
Cite this
Conservation approaches for the management of stage I/II carcinoma of the breast : Milan Cancer Institute Trials. / Veronesi, Umberto; Luini, Alberto; Galimberti, Viviana; Zurrida, Stefano.
In: World Journal of Surgery, Vol. 18, No. 1, 01.1994, p. 70-75.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Conservation approaches for the management of stage I/II carcinoma of the breast
T2 - Milan Cancer Institute Trials
AU - Veronesi, Umberto
AU - Luini, Alberto
AU - Galimberti, Viviana
AU - Zurrida, Stefano
PY - 1994/1
Y1 - 1994/1
N2 - The most recent analysis of the results of three major trials on breast conservation carried out at the Milan Cancer Institute between 1973 and 1988 showed that breast conservation consisting of a wide breast resection (quadrantectomy) plus radiotherapy is a safe procedure, and that there are no differences in long-term survival (up to 19 years) compared with women who have undergone Halsted's mastectomy. The studies also showed that reducing the extent of surgery from quadrantectomy to lumpectomy increases the risk of local recurrence by nearly three times, as does withdrawing radiotherapy. However, in women older than 55 years, quadrantectomy alone (without radiotherapy) may yield good results. Among the risk factors for local recurrence, a young age and the presence of an extensive intraductal component are the most significant.
AB - The most recent analysis of the results of three major trials on breast conservation carried out at the Milan Cancer Institute between 1973 and 1988 showed that breast conservation consisting of a wide breast resection (quadrantectomy) plus radiotherapy is a safe procedure, and that there are no differences in long-term survival (up to 19 years) compared with women who have undergone Halsted's mastectomy. The studies also showed that reducing the extent of surgery from quadrantectomy to lumpectomy increases the risk of local recurrence by nearly three times, as does withdrawing radiotherapy. However, in women older than 55 years, quadrantectomy alone (without radiotherapy) may yield good results. Among the risk factors for local recurrence, a young age and the presence of an extensive intraductal component are the most significant.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028314070&partnerID=8YFLogxK
U2 - 10.1007/BF00348194
DO - 10.1007/BF00348194
M3 - Article
C2 - 8197779
AN - SCOPUS:0028314070
VL - 18
SP - 70
EP - 75
JO - World Journal of Surgery
JF - World Journal of Surgery
SN - 0364-2313
IS - 1
ER -