OBJECTIVE: About 30% of Adult type granulosa cell tumors of the ovary (AGCTs) are diagnosed in fertile age. In stage I, conservative surgery (fertility-sparing surgery, FSS), either unilateral salpingo-oophorectomy (USO) or cystectomy are possible options. The aim of this study is to compare oncological outcomes of FSS and radical surgery (RS) in apparently stage I AGCTs treated within the MITO group (Multicenter Italian Trials in Ovarian cancer). METHODS: Survival curves were calculated using the Kaplan-Meier method and compared with log-rank test. The role of clinicopathological variables as prognostic factors for survival was assessed using Cox's regression. RESULTS: Two-hundred and twenty-nine patients were included; 32.6% received FSS, 67.4% RS. In the FSS group, 62.8% underwent USO, 16.7% cystectomy, 20.5% cystectomy followed by USO. After a median follow up of 84 months, median DFS was significantly worse in the FSS-group (10 yr DFS 50% vs 74%, in FSS and RS group, p = 0.006). No significant difference was detected between RS and USO (10 yr DFS 75% vs 70%, p = 0.5).Cystectomy-group showed a significantly worse DFS compared to USO (10 yr DFS 16% vs 70%, p 
Original languageEnglish
Pages (from-to)323-327
Number of pages5
JournalGynecologic Oncology
Issue number2
Publication statusPublished - Aug 2019


  • *Cystectomy
  • *Fertility sparing surgery
  • *Granulosa cell tumors
  • *Ovary
  • *Unilateral oophorectomy
  • Adult
  • Case-Control Studies
  • Female
  • Granulosa Cell Tumor/mortality/*surgery
  • Humans
  • Middle Aged
  • Organ Sparing Treatments/adverse effects/*methods
  • Ovarian Neoplasms/mortality/*surgery
  • Ovariectomy/adverse effects/standards
  • Proportional Hazards Models
  • Retrospective Studies
  • Salpingo-oophorectomy/adverse effects/statistics & numerical data


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