Conservative surgery in stage I adult type granulosa cells tumors of the ovary: Results from the MITO-9 study

A. Bergamini, G. Cormio, G. Ferrandina, D. Lorusso, G. Giorda, G. Scarfone, L. Bocciolone, F. Raspagliesi, S. Tateo, C. Cassani, A. Savarese, E. Breda, U. De Giorgi, F. Mascilini, M. Candiani, A. Kardhashi, N. Biglia, A. M. Perrone, S. Pignata, G. Mangili

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: About 30% of Adult type granulosa cell tumors of the ovary (AGCTs) are diagnosed in fertile age. In stage I, conservative surgery (fertility-sparing surgery, FSS), either unilateral salpingo-oophorectomy (USO) or cystectomy are possible options. The aim of this study is to compare oncological outcomes of FSS and radical surgery (RS) in apparently stage I AGCTs treated within the MITO group (Multicenter Italian Trials in Ovarian cancer). METHODS: Survival curves were calculated using the Kaplan-Meier method and compared with log-rank test. The role of clinicopathological variables as prognostic factors for survival was assessed using Cox's regression. RESULTS: Two-hundred and twenty-nine patients were included; 32.6% received FSS, 67.4% RS. In the FSS group, 62.8% underwent USO, 16.7% cystectomy, 20.5% cystectomy followed by USO. After a median follow up of 84months, median DFS was significantly worse in the FSS-group (10yr DFS 50% vs 74%, in FSS and RS group, p=0.006). No significant difference was detected between RS and USO (10yr DFS 75% vs 70%, p=0.5).Cystectomy-group showed a significantly worse DFS compared to USO (10yr DFS 16% vs 70%, p
Original languageItalian
Pages (from-to)323-327
Number of pages5
JournalGynecologic Oncology
Issue number2
Publication statusPublished - 2019

Cite this