Between January 1981 and May 1996, thirty patients with anal canal carcinoma were treated with a protocol of radiation therapy alone or in combination with chemotherapy. The patients were divided into 4 stages by International Union against Cancer (UICC) 1987: I stage 8 patients, II stage 16 patients, III stage 5 patients, nobody in stage IV and 1 patient in recurrence. Sixteen patients were treated with external radiation therapy alone, 8 with interstitial 192Ir implant alone, and 6 with the combination of both (dose range 30-70 Gy). Nine patients received concomitant cytotoxic chemotherapy. Toxicities were mild to moderate. Twenty-eight patients were eligible and 2 were lost to follow-up. A complete response (CR) was observed in 19 patients (68%); nobody of these patients had local recurrence and anorectal function was retained. We may conclude that radiotherapy with or without chemotherapy can provide a good local control and preserve anal function with acceptable morbidity.
|Number of pages||3|
|Journal||Radiology and Oncology|
|Publication status||Published - 1997|
- Rectal neoplasms-radiotherapy-drug therapy
- Treatment outcome
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging