TRAITEMENT CONSERVATIF DU CANCER DU SEIN. ESSAI THERAPEUTIQUE EN COURS A L'INSTITUT DU CANCER DE MILAN

Translated title of the contribution: Conservative treatment of breast cancer. A trial in progress at the Cancer Institute of Milan

U. Veronesi, R. Saccozzi, M. Greco, A. Luini, L. Sultan

Research output: Contribution to journalArticle

Abstract

The report describes a clinical trial on conservative surgery in progress at the National Cancer Institute of Milan, Italy. The randomized clinical trial compares radical mastectomy with a more conservative procedure consisting of mammary resection plus axillary dissection plus radiotherapy. The resection comprises an entire quadrant of the breast together with the overlying skin. After surgery the patients receive 6,000 rads to the residual breast tissue over 5 to 6 weeks, starting 15 days after operation. The cosmetic results are satisfactory in the majority of cases. The trial is limited to cases with tumors less than 2 cm (T 1N 0M 0). Patients with histologically positive lymph nodes (N+) are submitted to adjuvant chemotherapy with CMF for one year. From September 1973 to October 1976, 331 cases entered the trial. 167 were treated with radical mastectomy and 164 with conservative procedure. Axillary metastases were found in 23% of the radical and in 29% of the conservative surgery group. Four local-regional recurrences have occurred till now, 2 in each group. Five cases in the radical mastectomy group and 1 in the conservative group had distant metastases. The clinical trial will collect some 500 cases by the end of 1977 and significant preliminary results are expected to be available from the beginning of 1979.

Original languageFrench
Pages (from-to)619-625
Number of pages7
JournalBulletin du Cancer
Volume64
Issue number4
Publication statusPublished - 1977

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ASJC Scopus subject areas

  • Oncology

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