Conservative treatment of early endometrial cancer: Preliminary results of a pilot study

Giuseppe Laurelli, Giovanni Di Vagno, Cono Scaffa, Simona Losito, Maurizio Del Giudice, Stefano Greggi

Research output: Contribution to journalArticlepeer-review


Objective: This study evaluated the feasibility and efficacy of combined operative hysteroscopy (HSC) and hormone therapy as fertility-preserving treatment in a cohort of selected young women with early endometrial carcinoma (EC). Methods: Fourteen patients (median age 38 years, range 26-40) with FIGO stage IA (intramucous) EC wishing to preserve fertility were enrolled with the following inclusion criteria: age ≤ 40 years; no evidence of Lynch II syndrome; well-differentiated estrogen/progesterone receptor positive (ER+/PR+) endometrioid EC; no evidence of myoinvasion, multifocal tumor, node metastasis, ovarian mass; normal serum CA 125. Treatment consisted of hysteroscopic ablation of the lesion and the myometrial tissue below, followed by oral megestrol acetate (MA) 160 mg/day for 6 months (6 pts) or 52 mg levonorgestrel-medicated intrauterine device (LNG-IUD) for 12 months (8 pts). Results: With a median follow-up of 40 months (range 13-79), one patient recurred after 5 months from operative HSC and underwent definitive surgery, one patient showed an endometrial hyperplasia without atypia at the 3 and 6 month HSC control, with negative controls thereafter. Three patients have attempted to conceive and one of them conceived and term delivered a healthy baby. Conclusions: Combined operative HSC and progestin therapy may have a role for safe and effective conservative management of early EC in selected patients wishing to preserve fertility.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalGynecologic Oncology
Issue number1
Publication statusPublished - Jan 2011


  • Conservative treatment
  • Endometrial cancer
  • Hysteroscopy
  • Progestin therapy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology


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