Consistency of neuropsychiatric syndromes across dementias

Results from the European Alzheimer Disease Consortium - Part II

Pauline Aalten, Frans R J Verhey, Marina Boziki, Andrea Brugnolo, Roger Bullock, Eleanor Jane Byrne, Vincent Camus, Miriam Caputo, Debby Collins, Peter Paul De Deyn, Kazi Elina, Giovanni Frisoni, Clive Holmes, Catherine Hurt, Anna Marriott, Patrizia Mecocci, Flavio Nobili, Pierre Jean Ousset, Emma Reynish, Eric Salmon & 3 others Magda Tsolaki, Bruno Vellas, Philippe H. Robert

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Background/Aims: The aim of this study was to determine the consistency of neuropsychiatric subsyndromes of the Neuropsychiatric Inventory across several clinical and demographic subgroups (e.g. dementia subtypes, dementia severity, medication use, age and gender) in a large sample of outpatients with dementia. Methods: Cross-sectional data of 2,808 patients with dementia from 12 centres from the European Alzheimer's Disease Consortium were collected. Principal component analysis was used for factor analysis. Subanalyses were performed for dementia subtypes, dementia severity, medication use, age and gender. Results: The results showed the relatively consistent presence of the 4 neuropsychiatric subsyndromes 'hyperactivity', 'psychosis', 'affective symptoms' and 'apathy' across the subanalyses. The factor structure was not dependent on dementia subtypes, age and gender but was dependent on dementia severity and cholinesterase use. The factors hyperactivity and affective symptoms were present in all subanalyses, but the presence of the factors apathy and psychosis was dependent on use of cholinesterase inhibitors and dementia severity, respectively. Conclusion: The present study provided evidence of the relative consistency of neuropsychiatric subsyndromes across dementia subtypes, age and gender, thereby stressing the importance of thinking about neuropsychiatric subsyndromes instead of separate symptoms. However, the subsyndromes apathy and psychosis were dependent on use of cholinesterase inhibitors and dementia severity.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalDementia and Geriatric Cognitive Disorders
Volume25
Issue number1
DOIs
Publication statusPublished - Dec 2007

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Dementia
Alzheimer Disease
Apathy
Psychotic Disorders
Affective Symptoms
Cholinesterase Inhibitors
Cholinesterases
Principal Component Analysis
Statistical Factor Analysis
Outpatients
Demography
Equipment and Supplies

Keywords

  • Dementia
  • European Alzheimer's Disease Consortium
  • Neuropsychiatric analysis
  • Neuropsychiatric syndromes
  • Subsyndromes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

Cite this

Consistency of neuropsychiatric syndromes across dementias : Results from the European Alzheimer Disease Consortium - Part II. / Aalten, Pauline; Verhey, Frans R J; Boziki, Marina; Brugnolo, Andrea; Bullock, Roger; Byrne, Eleanor Jane; Camus, Vincent; Caputo, Miriam; Collins, Debby; De Deyn, Peter Paul; Elina, Kazi; Frisoni, Giovanni; Holmes, Clive; Hurt, Catherine; Marriott, Anna; Mecocci, Patrizia; Nobili, Flavio; Ousset, Pierre Jean; Reynish, Emma; Salmon, Eric; Tsolaki, Magda; Vellas, Bruno; Robert, Philippe H.

In: Dementia and Geriatric Cognitive Disorders, Vol. 25, No. 1, 12.2007, p. 1-8.

Research output: Contribution to journalArticle

Aalten, P, Verhey, FRJ, Boziki, M, Brugnolo, A, Bullock, R, Byrne, EJ, Camus, V, Caputo, M, Collins, D, De Deyn, PP, Elina, K, Frisoni, G, Holmes, C, Hurt, C, Marriott, A, Mecocci, P, Nobili, F, Ousset, PJ, Reynish, E, Salmon, E, Tsolaki, M, Vellas, B & Robert, PH 2007, 'Consistency of neuropsychiatric syndromes across dementias: Results from the European Alzheimer Disease Consortium - Part II', Dementia and Geriatric Cognitive Disorders, vol. 25, no. 1, pp. 1-8. https://doi.org/10.1159/000111082
Aalten, Pauline ; Verhey, Frans R J ; Boziki, Marina ; Brugnolo, Andrea ; Bullock, Roger ; Byrne, Eleanor Jane ; Camus, Vincent ; Caputo, Miriam ; Collins, Debby ; De Deyn, Peter Paul ; Elina, Kazi ; Frisoni, Giovanni ; Holmes, Clive ; Hurt, Catherine ; Marriott, Anna ; Mecocci, Patrizia ; Nobili, Flavio ; Ousset, Pierre Jean ; Reynish, Emma ; Salmon, Eric ; Tsolaki, Magda ; Vellas, Bruno ; Robert, Philippe H. / Consistency of neuropsychiatric syndromes across dementias : Results from the European Alzheimer Disease Consortium - Part II. In: Dementia and Geriatric Cognitive Disorders. 2007 ; Vol. 25, No. 1. pp. 1-8.
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AU - Brugnolo, Andrea

AU - Bullock, Roger

AU - Byrne, Eleanor Jane

AU - Camus, Vincent

AU - Caputo, Miriam

AU - Collins, Debby

AU - De Deyn, Peter Paul

AU - Elina, Kazi

AU - Frisoni, Giovanni

AU - Holmes, Clive

AU - Hurt, Catherine

AU - Marriott, Anna

AU - Mecocci, Patrizia

AU - Nobili, Flavio

AU - Ousset, Pierre Jean

AU - Reynish, Emma

AU - Salmon, Eric

AU - Tsolaki, Magda

AU - Vellas, Bruno

AU - Robert, Philippe H.

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N2 - Background/Aims: The aim of this study was to determine the consistency of neuropsychiatric subsyndromes of the Neuropsychiatric Inventory across several clinical and demographic subgroups (e.g. dementia subtypes, dementia severity, medication use, age and gender) in a large sample of outpatients with dementia. Methods: Cross-sectional data of 2,808 patients with dementia from 12 centres from the European Alzheimer's Disease Consortium were collected. Principal component analysis was used for factor analysis. Subanalyses were performed for dementia subtypes, dementia severity, medication use, age and gender. Results: The results showed the relatively consistent presence of the 4 neuropsychiatric subsyndromes 'hyperactivity', 'psychosis', 'affective symptoms' and 'apathy' across the subanalyses. The factor structure was not dependent on dementia subtypes, age and gender but was dependent on dementia severity and cholinesterase use. The factors hyperactivity and affective symptoms were present in all subanalyses, but the presence of the factors apathy and psychosis was dependent on use of cholinesterase inhibitors and dementia severity, respectively. Conclusion: The present study provided evidence of the relative consistency of neuropsychiatric subsyndromes across dementia subtypes, age and gender, thereby stressing the importance of thinking about neuropsychiatric subsyndromes instead of separate symptoms. However, the subsyndromes apathy and psychosis were dependent on use of cholinesterase inhibitors and dementia severity.

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