Constant mean airway pressure with different patterns of positive pressure breathing during the adult respiratory distress syndrome

L. Gattinoni, R. Marcolin, M. L. Caspani, R. Fumagalli, D. Mascheroni, A. Pesenti

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-one ARDS patients were divided into two groups of severity according to FIO2 and PEEP required to maintain an adequate gas exchange. The 10 most severe patients (group A) underwent continuous positive pressure ventilation (CPPV) (I/E 3:1) with the mean airway pressure maintained at 21 ± 6.2 cmH2O. The PEEP values were 12.6 ± 4.3 cmH2O during CPPV and 6.5 ± 3.7 cmH2O during IRV (p 2O. The PEEP was 7 ± 2.5 cmH2O during CPPV and 14.9 ± 4.3 cmH2O during CPAP (p 6 shunt was measured as representative of true shunt. The results showed that gas exchange, including true shunt, and haemodynamics did not change between CPPV and IRV and between CPPV and CPAP tests. Taken with previous work on mean airway pressure, our results further support the concept that the main determinant of oxygenation and haemodynamics is the mean airway pressure, irrespective of the PEEP level and of the mode of ventilation.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalClinical Respiratory Physiology
Volume21
Issue number3
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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