TY - JOUR
T1 - Constant transmission properties of variant Creutzfeldt-Jakob disease in 5 countries
AU - Diack, Abigail B.
AU - Ritchie, Diane
AU - Bishop, Matthew
AU - Pinion, Victoria
AU - Brandel, Jean Philippe
AU - Haik, Stephane
AU - Tagliavini, Fabrizio
AU - Van Duijn, Cornelia
AU - Belay, Ermias D.
AU - Gambetti, Pierluigi
AU - Schonberger, Lawrence B.
AU - Piccardo, Pedro
AU - Will, Robert G.
AU - Manson, Jean C.
PY - 2012/10
Y1 - 2012/10
N2 - Variant Creutzfeldt-Jakob disease (vCJD) has been reported in 12 countries. We hypothesized that a common strain of agent is responsible for all vCJD cases, regardless of geographic origin. To test this hypothesis, we inoculated strain-typing panels of wild-type mice with brain material from human vCJD case-patients from France, the Netherlands, Italy, and the United States. Mice were assessed for clinical disease, neuropathologic changes, and glycoform profile; results were compared with those for 2 reference vCJD cases from the United Kingdom. Transmission to mice occurred from each sample tested, and data were similar between non-UK and UK cases, with the exception of the ranking of mean clinical incubation times of mouse lines. These findings support the hypothesis that a single strain of infectious agent is responsible for all vCJD infections. However, differences in incubation times require further subpassage in mice to establish any true differences in strain properties between cases.
AB - Variant Creutzfeldt-Jakob disease (vCJD) has been reported in 12 countries. We hypothesized that a common strain of agent is responsible for all vCJD cases, regardless of geographic origin. To test this hypothesis, we inoculated strain-typing panels of wild-type mice with brain material from human vCJD case-patients from France, the Netherlands, Italy, and the United States. Mice were assessed for clinical disease, neuropathologic changes, and glycoform profile; results were compared with those for 2 reference vCJD cases from the United Kingdom. Transmission to mice occurred from each sample tested, and data were similar between non-UK and UK cases, with the exception of the ranking of mean clinical incubation times of mouse lines. These findings support the hypothesis that a single strain of infectious agent is responsible for all vCJD infections. However, differences in incubation times require further subpassage in mice to establish any true differences in strain properties between cases.
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U2 - 10.3201/eid1810.120792
DO - 10.3201/eid1810.120792
M3 - Article
C2 - 23017202
AN - SCOPUS:84866538883
VL - 18
SP - 1574
EP - 1579
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
SN - 1080-6040
IS - 10
ER -