Constitutive heterochromatin

A surprising variety of expressed sequences

Patrizio Dimitri, Ruggiero Caizzi, Ennio Giordano, Maria Carmela Accardo, Giovanna Lattanzi, Giuseppe Biamonti

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The organization of chromosomes into euchromatin and heterochromatin is amongst the most important and enigmatic aspects of genome evolution. Constitutive heterochromatin is a basic yet still poorly understood component of eukaryotic chromosomes, and its molecular characterization by means of standard genomic approaches is intrinsically difficult. Although recent evidence indicates that the presence of transcribed genes in constitutive heterochromatin is a conserved trait that accompanies the evolution of eukaryotic genomes, the term heterochromatin is still considered by many as synonymous of gene silencing. In this paper, we comprehensively review data that provide a clearer picture of transcribed sequences within constitutive heterochromatin, with a special emphasis on Drosophila and humans.

Original languageEnglish
Pages (from-to)419-435
Number of pages17
JournalChromosoma
Volume118
Issue number4
DOIs
Publication statusPublished - 2009

Fingerprint

Heterochromatin
Chromosomes
Genome
Euchromatin
Gene Silencing
Drosophila
Genes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Dimitri, P., Caizzi, R., Giordano, E., Carmela Accardo, M., Lattanzi, G., & Biamonti, G. (2009). Constitutive heterochromatin: A surprising variety of expressed sequences. Chromosoma, 118(4), 419-435. https://doi.org/10.1007/s00412-009-0211-y

Constitutive heterochromatin : A surprising variety of expressed sequences. / Dimitri, Patrizio; Caizzi, Ruggiero; Giordano, Ennio; Carmela Accardo, Maria; Lattanzi, Giovanna; Biamonti, Giuseppe.

In: Chromosoma, Vol. 118, No. 4, 2009, p. 419-435.

Research output: Contribution to journalArticle

Dimitri, P, Caizzi, R, Giordano, E, Carmela Accardo, M, Lattanzi, G & Biamonti, G 2009, 'Constitutive heterochromatin: A surprising variety of expressed sequences', Chromosoma, vol. 118, no. 4, pp. 419-435. https://doi.org/10.1007/s00412-009-0211-y
Dimitri, Patrizio ; Caizzi, Ruggiero ; Giordano, Ennio ; Carmela Accardo, Maria ; Lattanzi, Giovanna ; Biamonti, Giuseppe. / Constitutive heterochromatin : A surprising variety of expressed sequences. In: Chromosoma. 2009 ; Vol. 118, No. 4. pp. 419-435.
@article{d77d901bbc8e4087b872bb91223bf179,
title = "Constitutive heterochromatin: A surprising variety of expressed sequences",
abstract = "The organization of chromosomes into euchromatin and heterochromatin is amongst the most important and enigmatic aspects of genome evolution. Constitutive heterochromatin is a basic yet still poorly understood component of eukaryotic chromosomes, and its molecular characterization by means of standard genomic approaches is intrinsically difficult. Although recent evidence indicates that the presence of transcribed genes in constitutive heterochromatin is a conserved trait that accompanies the evolution of eukaryotic genomes, the term heterochromatin is still considered by many as synonymous of gene silencing. In this paper, we comprehensively review data that provide a clearer picture of transcribed sequences within constitutive heterochromatin, with a special emphasis on Drosophila and humans.",
author = "Patrizio Dimitri and Ruggiero Caizzi and Ennio Giordano and {Carmela Accardo}, Maria and Giovanna Lattanzi and Giuseppe Biamonti",
year = "2009",
doi = "10.1007/s00412-009-0211-y",
language = "English",
volume = "118",
pages = "419--435",
journal = "Chromosoma",
issn = "0009-5915",
publisher = "Springer Science and Business Media Deutschland GmbH",
number = "4",

}

TY - JOUR

T1 - Constitutive heterochromatin

T2 - A surprising variety of expressed sequences

AU - Dimitri, Patrizio

AU - Caizzi, Ruggiero

AU - Giordano, Ennio

AU - Carmela Accardo, Maria

AU - Lattanzi, Giovanna

AU - Biamonti, Giuseppe

PY - 2009

Y1 - 2009

N2 - The organization of chromosomes into euchromatin and heterochromatin is amongst the most important and enigmatic aspects of genome evolution. Constitutive heterochromatin is a basic yet still poorly understood component of eukaryotic chromosomes, and its molecular characterization by means of standard genomic approaches is intrinsically difficult. Although recent evidence indicates that the presence of transcribed genes in constitutive heterochromatin is a conserved trait that accompanies the evolution of eukaryotic genomes, the term heterochromatin is still considered by many as synonymous of gene silencing. In this paper, we comprehensively review data that provide a clearer picture of transcribed sequences within constitutive heterochromatin, with a special emphasis on Drosophila and humans.

AB - The organization of chromosomes into euchromatin and heterochromatin is amongst the most important and enigmatic aspects of genome evolution. Constitutive heterochromatin is a basic yet still poorly understood component of eukaryotic chromosomes, and its molecular characterization by means of standard genomic approaches is intrinsically difficult. Although recent evidence indicates that the presence of transcribed genes in constitutive heterochromatin is a conserved trait that accompanies the evolution of eukaryotic genomes, the term heterochromatin is still considered by many as synonymous of gene silencing. In this paper, we comprehensively review data that provide a clearer picture of transcribed sequences within constitutive heterochromatin, with a special emphasis on Drosophila and humans.

UR - http://www.scopus.com/inward/record.url?scp=67649499976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649499976&partnerID=8YFLogxK

U2 - 10.1007/s00412-009-0211-y

DO - 10.1007/s00412-009-0211-y

M3 - Article

VL - 118

SP - 419

EP - 435

JO - Chromosoma

JF - Chromosoma

SN - 0009-5915

IS - 4

ER -