Constitutive transport between the trans-Golgi network and the plasma membrane according to the maturation model. A hypothesis

Alexander A. Mironov, Alberto Luini, Roberto Buccione

Research output: Contribution to journalArticle

Abstract

Here we examine the application of the cisternal/carrier maturation model to describe transport of cargo proteins from the Golgi apparatus to the plasma membrane. Interpretation of the available evidence in the light of carrier maturation suggests that the transport intermediates between these stations are large pleiomorphic carriers formed by maturation of the trans-Golgi compartment, rather than vesicles, as would be postulated by the vesicular shuttle model. Mature carriers move along microtubules towards the plasma membrane via a microtubule/(kinesin)-based motor system. The maturation and vesicular transport models are compared in terms of consistency with the available literature. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
JournalFEBS Letters
Volume440
Issue number1-2
Publication statusPublished - Nov 27 1998

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trans-Golgi Network
Cell membranes
Microtubules
Cell Membrane
Kinesin
Golgi Apparatus
Carrier Proteins
Proteins

Keywords

  • Carrier maturation
  • Cisterna maturation
  • Golgi-plasmalemma transport
  • Lateral diffusion

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Constitutive transport between the trans-Golgi network and the plasma membrane according to the maturation model. A hypothesis. / Mironov, Alexander A.; Luini, Alberto; Buccione, Roberto.

In: FEBS Letters, Vol. 440, No. 1-2, 27.11.1998, p. 93-96.

Research output: Contribution to journalArticle

Mironov, Alexander A. ; Luini, Alberto ; Buccione, Roberto. / Constitutive transport between the trans-Golgi network and the plasma membrane according to the maturation model. A hypothesis. In: FEBS Letters. 1998 ; Vol. 440, No. 1-2. pp. 93-96.
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