Constrained spherical deconvolution-based tractography to depict and characterize a case of "hyperplastic fornix dorsalis"

Valeria Elisa Contarino, Sara Bulgheroni, Mario Savoiardo, Silvia Annunziata, Domenico Aquino, Daria Riva, Alessandra Erbetta

Research output: Contribution to journalArticlepeer-review


The authors report the relevance of Constrained Spherical Deconvolution (CSD)-based tractography in demonstrating and quantitatively assessing a complex midline structure malformation in a 9-year-old girl with moderate intellectual disability and thickening of corpus callosum (CC) body discovered through conventional MRI (cMRI). Color-encoded fractional anisotropy (FA) maps clearly demonstrated what the cMRI showed as a thicknening of CC: a green, longitudinal bundle running dorsally to the body of CC. A more complex midline maldevelopmental disorder was suspected. CSD-based tractography was performed to virtually dissect the anomalous supracallosal longitudinal bundle (SLB), CC, fornix, anterior commissure (AC) and cingula. In addition, DTI-derived metrics were calculated for each virtually dissected fiber tract.The tractography study evidenced projections of the anomalous SLB in left forceps minor and to parietal regions, and projections of the fornix in right forceps minor. CC virtual dissection showed no gross abnormality, and cingula appeared slightly less extended than normal. The considerable thinning of AC hampered its virtual dissection. DTI-derived metrics suggested alterations in fornix microstructure, attributable to higher fiber density.In investigating white matter, cMRI may not be sufficient in addressing and assessing possible anomalies, while advanced CSD-based tractography and DTI-derived metrics may prove helpful in depicting and characterizing white matter anomalies in developmental disorders.

Original languageEnglish
Pages (from-to)1428-1433
Number of pages6
JournalMagnetic Resonance Imaging
Issue number10
Publication statusPublished - 2014


  • Constrained spherical deconvolution-based tractography
  • Diffusion Tensor Imaging
  • Intellectual disability
  • Midline malformations
  • Supracallosal bundle

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering


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