Constraint-Induced Movement Therapy in multiple sclerosis: Safety and three-dimensional kinematic analysis of upper limb activity. A randomized single-blind pilot study

Alessandro de Sire, Matteo Bigoni, Lorenzo Priano, Silvia Baudo, Claudio Solaro, Alessandro Mauro

Research output: Contribution to journalArticle

Abstract

BACKGROUND: There are few evidences on safety of Constraint-Induced Movement Therapy (CIMT), as well as its effects in neurological conditions, including multiple sclerosis (MS). OBJECTIVE: To evaluate safety and effectiveness of a 2-week CIMT protocol on upper limb activity of progressive MS patients through a three-dimensional (3D) kinematic analysis. METHODS: In this randomized single-blind pilot study, we randomly allocated patients affected by progressive MS reporting a reduced use of one upper limb into two different groups: CIMT group (less affected limb blocked by a splint) and control group (undergoing bi-manual treatment). Primary outcome was CIMT safety. Furthermore, we assessed CIMT effects through clinical outcomes (hand grip strength, HGS, and 9 Hole Peg Test, 9HPT) and 3D kinematic analysis (normalized jerk, number of movement units, going phase duration, mean velocity, endpoint error). All evaluations were performed at baseline (T0) and after 2 weeks of treatment (T1) for both arms in both groups. RESULTS: Ten MS patients, mean aged 51.0±7.7 years, were randomly allocated in the 2 groups. After treatment, no differences were found in the blocked arm. Furthermore, CIMT group showed significant improvements in clinical and kinematic parameters. CONCLUSIONS: CIMT might be considered a safe and effective technique in MS patients.

Original languageEnglish
Pages (from-to)247-254
Number of pages8
JournalNeuroRehabilitation
Volume45
Issue number2
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Single-Blind Method
Biomechanical Phenomena
Upper Extremity
Multiple Sclerosis
Safety
Hand Strength
Therapeutics
Group Psychotherapy
Arm
Splints
Extremities
Control Groups

Keywords

  • constraint-induced movement therapy
  • kinematics
  • Multiple sclerosis
  • muscle strength
  • physical therapy modalities
  • rehabilitation
  • upper extremity

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Clinical Neurology

Cite this

Constraint-Induced Movement Therapy in multiple sclerosis : Safety and three-dimensional kinematic analysis of upper limb activity. A randomized single-blind pilot study. / de Sire, Alessandro; Bigoni, Matteo; Priano, Lorenzo; Baudo, Silvia; Solaro, Claudio; Mauro, Alessandro.

In: NeuroRehabilitation, Vol. 45, No. 2, 01.01.2019, p. 247-254.

Research output: Contribution to journalArticle

@article{23971e04f4b7482eb6aca30aa34aefae,
title = "Constraint-Induced Movement Therapy in multiple sclerosis: Safety and three-dimensional kinematic analysis of upper limb activity. A randomized single-blind pilot study",
abstract = "BACKGROUND: There are few evidences on safety of Constraint-Induced Movement Therapy (CIMT), as well as its effects in neurological conditions, including multiple sclerosis (MS). OBJECTIVE: To evaluate safety and effectiveness of a 2-week CIMT protocol on upper limb activity of progressive MS patients through a three-dimensional (3D) kinematic analysis. METHODS: In this randomized single-blind pilot study, we randomly allocated patients affected by progressive MS reporting a reduced use of one upper limb into two different groups: CIMT group (less affected limb blocked by a splint) and control group (undergoing bi-manual treatment). Primary outcome was CIMT safety. Furthermore, we assessed CIMT effects through clinical outcomes (hand grip strength, HGS, and 9 Hole Peg Test, 9HPT) and 3D kinematic analysis (normalized jerk, number of movement units, going phase duration, mean velocity, endpoint error). All evaluations were performed at baseline (T0) and after 2 weeks of treatment (T1) for both arms in both groups. RESULTS: Ten MS patients, mean aged 51.0±7.7 years, were randomly allocated in the 2 groups. After treatment, no differences were found in the blocked arm. Furthermore, CIMT group showed significant improvements in clinical and kinematic parameters. CONCLUSIONS: CIMT might be considered a safe and effective technique in MS patients.",
keywords = "constraint-induced movement therapy, kinematics, Multiple sclerosis, muscle strength, physical therapy modalities, rehabilitation, upper extremity",
author = "{de Sire}, Alessandro and Matteo Bigoni and Lorenzo Priano and Silvia Baudo and Claudio Solaro and Alessandro Mauro",
year = "2019",
month = "1",
day = "1",
doi = "10.3233/NRE-192762",
language = "English",
volume = "45",
pages = "247--254",
journal = "NeuroRehabilitation",
issn = "1053-8135",
publisher = "IOS Press",
number = "2",

}

TY - JOUR

T1 - Constraint-Induced Movement Therapy in multiple sclerosis

T2 - Safety and three-dimensional kinematic analysis of upper limb activity. A randomized single-blind pilot study

AU - de Sire, Alessandro

AU - Bigoni, Matteo

AU - Priano, Lorenzo

AU - Baudo, Silvia

AU - Solaro, Claudio

AU - Mauro, Alessandro

PY - 2019/1/1

Y1 - 2019/1/1

N2 - BACKGROUND: There are few evidences on safety of Constraint-Induced Movement Therapy (CIMT), as well as its effects in neurological conditions, including multiple sclerosis (MS). OBJECTIVE: To evaluate safety and effectiveness of a 2-week CIMT protocol on upper limb activity of progressive MS patients through a three-dimensional (3D) kinematic analysis. METHODS: In this randomized single-blind pilot study, we randomly allocated patients affected by progressive MS reporting a reduced use of one upper limb into two different groups: CIMT group (less affected limb blocked by a splint) and control group (undergoing bi-manual treatment). Primary outcome was CIMT safety. Furthermore, we assessed CIMT effects through clinical outcomes (hand grip strength, HGS, and 9 Hole Peg Test, 9HPT) and 3D kinematic analysis (normalized jerk, number of movement units, going phase duration, mean velocity, endpoint error). All evaluations were performed at baseline (T0) and after 2 weeks of treatment (T1) for both arms in both groups. RESULTS: Ten MS patients, mean aged 51.0±7.7 years, were randomly allocated in the 2 groups. After treatment, no differences were found in the blocked arm. Furthermore, CIMT group showed significant improvements in clinical and kinematic parameters. CONCLUSIONS: CIMT might be considered a safe and effective technique in MS patients.

AB - BACKGROUND: There are few evidences on safety of Constraint-Induced Movement Therapy (CIMT), as well as its effects in neurological conditions, including multiple sclerosis (MS). OBJECTIVE: To evaluate safety and effectiveness of a 2-week CIMT protocol on upper limb activity of progressive MS patients through a three-dimensional (3D) kinematic analysis. METHODS: In this randomized single-blind pilot study, we randomly allocated patients affected by progressive MS reporting a reduced use of one upper limb into two different groups: CIMT group (less affected limb blocked by a splint) and control group (undergoing bi-manual treatment). Primary outcome was CIMT safety. Furthermore, we assessed CIMT effects through clinical outcomes (hand grip strength, HGS, and 9 Hole Peg Test, 9HPT) and 3D kinematic analysis (normalized jerk, number of movement units, going phase duration, mean velocity, endpoint error). All evaluations were performed at baseline (T0) and after 2 weeks of treatment (T1) for both arms in both groups. RESULTS: Ten MS patients, mean aged 51.0±7.7 years, were randomly allocated in the 2 groups. After treatment, no differences were found in the blocked arm. Furthermore, CIMT group showed significant improvements in clinical and kinematic parameters. CONCLUSIONS: CIMT might be considered a safe and effective technique in MS patients.

KW - constraint-induced movement therapy

KW - kinematics

KW - Multiple sclerosis

KW - muscle strength

KW - physical therapy modalities

KW - rehabilitation

KW - upper extremity

UR - http://www.scopus.com/inward/record.url?scp=85074745591&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074745591&partnerID=8YFLogxK

U2 - 10.3233/NRE-192762

DO - 10.3233/NRE-192762

M3 - Article

C2 - 31498137

AN - SCOPUS:85074745591

VL - 45

SP - 247

EP - 254

JO - NeuroRehabilitation

JF - NeuroRehabilitation

SN - 1053-8135

IS - 2

ER -