Construction of a genetic map telomeric to HAL-A by microsatellite analysis

C. Camaschella, A. Roetto, G. De Sandre, A. Piperno, A. Totaro, I. Dianzani, P. Gasparini

Research output: Contribution to journalArticle

Abstract

Allele and genotype frquencies of five microsatellites on the short arm of chromosome 6 have been determined in 158 subjects from 14 large Italian families, using polymerase chain reaction amplification and a non-radioactive method of detection. The markers studied were: D6S89, D6S109, D6S105, pLR12 and HLA-F; their heterozygosity ranged from 0.65 to 0.78. Two point and three point linkage analysis among these markers and HLA-A serological types - available for all the studied samples - allowed construction of a partial genetic map telomeric to HLA-A. Our results may be useful for linkage anlaysis of genetic disorders mapping on this region of 6 p.

Original languageEnglish
Pages (from-to)411-414
Number of pages4
JournalMolecular and Cellular Probes
Volume7
Issue number5
DOIs
Publication statusPublished - 1993

Keywords

  • chromosome 6
  • Genetic map
  • Linkage analysis
  • Microsatellites

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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    Camaschella, C., Roetto, A., De Sandre, G., Piperno, A., Totaro, A., Dianzani, I., & Gasparini, P. (1993). Construction of a genetic map telomeric to HAL-A by microsatellite analysis. Molecular and Cellular Probes, 7(5), 411-414. https://doi.org/10.1006/mcpr.1993.1060