Construction of a genetic map telomeric to HAL-A by microsatellite analysis

C. Camaschella; A. Roetto; G. De Sandre; A. Piperno; A. Totaro; I. Dianzani; P. Gasparini

doi:10.1006/mcpr.1993.1060

Construction of a genetic map telomeric to HAL-A by microsatellite analysis

C. Camaschella, A. Roetto, G. De Sandre, A. Piperno, A. Totaro, I. Dianzani, P. Gasparini

Research output: Contribution to journal › Article › peer-review

Abstract

Allele and genotype frquencies of five microsatellites on the short arm of chromosome 6 have been determined in 158 subjects from 14 large Italian families, using polymerase chain reaction amplification and a non-radioactive method of detection. The markers studied were: D6S89, D6S109, D6S105, pLR12 and HLA-F; their heterozygosity ranged from 0.65 to 0.78. Two point and three point linkage analysis among these markers and HLA-A serological types - available for all the studied samples - allowed construction of a partial genetic map telomeric to HLA-A. Our results may be useful for linkage anlaysis of genetic disorders mapping on this region of 6 p.

Original language	English
Pages (from-to)	411-414
Number of pages	4
Journal	Molecular and Cellular Probes
Volume	7
Issue number	5
DOIs	https://doi.org/10.1006/mcpr.1993.1060
Publication status	Published - 1993

Keywords

chromosome 6
Genetic map
Linkage analysis
Microsatellites

ASJC Scopus subject areas

Cell Biology
Molecular Biology

Access to Document

10.1006/mcpr.1993.1060

Cite this

@article{97717d1741334ef58df3bc0db0f19f06,

title = "Construction of a genetic map telomeric to HAL-A by microsatellite analysis",

abstract = "Allele and genotype frquencies of five microsatellites on the short arm of chromosome 6 have been determined in 158 subjects from 14 large Italian families, using polymerase chain reaction amplification and a non-radioactive method of detection. The markers studied were: D6S89, D6S109, D6S105, pLR12 and HLA-F; their heterozygosity ranged from 0.65 to 0.78. Two point and three point linkage analysis among these markers and HLA-A serological types - available for all the studied samples - allowed construction of a partial genetic map telomeric to HLA-A. Our results may be useful for linkage anlaysis of genetic disorders mapping on this region of 6 p.",

keywords = "chromosome 6, Genetic map, Linkage analysis, Microsatellites",

author = "C. Camaschella and A. Roetto and {De Sandre}, G. and A. Piperno and A. Totaro and I. Dianzani and P. Gasparini",

year = "1993",

doi = "10.1006/mcpr.1993.1060",

language = "English",

volume = "7",

pages = "411--414",

journal = "Molecular and Cellular Probes",

issn = "0890-8508",

publisher = "Academic Press Inc.",

number = "5",

}

TY - JOUR

T1 - Construction of a genetic map telomeric to HAL-A by microsatellite analysis

AU - Camaschella, C.

AU - Roetto, A.

AU - De Sandre, G.

AU - Piperno, A.

AU - Totaro, A.

AU - Dianzani, I.

AU - Gasparini, P.

PY - 1993

Y1 - 1993

N2 - Allele and genotype frquencies of five microsatellites on the short arm of chromosome 6 have been determined in 158 subjects from 14 large Italian families, using polymerase chain reaction amplification and a non-radioactive method of detection. The markers studied were: D6S89, D6S109, D6S105, pLR12 and HLA-F; their heterozygosity ranged from 0.65 to 0.78. Two point and three point linkage analysis among these markers and HLA-A serological types - available for all the studied samples - allowed construction of a partial genetic map telomeric to HLA-A. Our results may be useful for linkage anlaysis of genetic disorders mapping on this region of 6 p.

AB - Allele and genotype frquencies of five microsatellites on the short arm of chromosome 6 have been determined in 158 subjects from 14 large Italian families, using polymerase chain reaction amplification and a non-radioactive method of detection. The markers studied were: D6S89, D6S109, D6S105, pLR12 and HLA-F; their heterozygosity ranged from 0.65 to 0.78. Two point and three point linkage analysis among these markers and HLA-A serological types - available for all the studied samples - allowed construction of a partial genetic map telomeric to HLA-A. Our results may be useful for linkage anlaysis of genetic disorders mapping on this region of 6 p.

KW - chromosome 6

KW - Genetic map

KW - Linkage analysis

KW - Microsatellites

UR - http://www.scopus.com/inward/record.url?scp=0027361646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027361646&partnerID=8YFLogxK

U2 - 10.1006/mcpr.1993.1060

DO - 10.1006/mcpr.1993.1060

M3 - Article

C2 - 8264675

AN - SCOPUS:0027361646

VL - 7

SP - 411

EP - 414

JO - Molecular and Cellular Probes

JF - Molecular and Cellular Probes

SN - 0890-8508

IS - 5

ER -

Construction of a genetic map telomeric to HAL-A by microsatellite analysis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this