Abstract
Allele and genotype frquencies of five microsatellites on the short arm of chromosome 6 have been determined in 158 subjects from 14 large Italian families, using polymerase chain reaction amplification and a non-radioactive method of detection. The markers studied were: D6S89, D6S109, D6S105, pLR12 and HLA-F; their heterozygosity ranged from 0.65 to 0.78. Two point and three point linkage analysis among these markers and HLA-A serological types - available for all the studied samples - allowed construction of a partial genetic map telomeric to HLA-A. Our results may be useful for linkage anlaysis of genetic disorders mapping on this region of 6 p.
| Original language | English |
|---|---|
| Pages (from-to) | 411-414 |
| Number of pages | 4 |
| Journal | Molecular and Cellular Probes |
| Volume | 7 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1993 |
Keywords
- chromosome 6
- Genetic map
- Linkage analysis
- Microsatellites
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
Fingerprint Dive into the research topics of 'Construction of a genetic map telomeric to HAL-A by microsatellite analysis'. Together they form a unique fingerprint.
Cite this
Camaschella, C., Roetto, A., De Sandre, G., Piperno, A., Totaro, A., Dianzani, I., & Gasparini, P. (1993). Construction of a genetic map telomeric to HAL-A by microsatellite analysis. Molecular and Cellular Probes, 7(5), 411-414. https://doi.org/10.1006/mcpr.1993.1060