Construction of a YAC contig covering human chromosome 6p22

Patrizia Malaspina, Antonella Roetto, Flavia Trettel, Carla Jodice, Paola Blasi, Marina Frontali, Massimo Carella, Brunella Franco, Clara Camaschella, Andrea Novelletto

Research output: Contribution to journalArticle

Abstract

A contig covering human chromosome 6p22 that consists of 134 YAC clones aligned based on the presence/absence of 52 DNA markers is presented. This contig overlaps with the 6p23 contig at its telomeric end and with the 6p21.3 contig at its centromeric end. The order of loci within the contig resolves the relative positions of several genetically mapped markers. Among the additional markers used here, there are eight novel PCR assays. The 12 known genes and anonymous ESTs located within the contig establish a first step toward a transcriptional map of this region. The instability of YAC clones observed during this work is also discussed.

Original languageEnglish
Pages (from-to)399-407
Number of pages9
JournalGenomics
Volume36
Issue number3
DOIs
Publication statusPublished - Sep 15 1996

ASJC Scopus subject areas

  • Genetics

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    Malaspina, P., Roetto, A., Trettel, F., Jodice, C., Blasi, P., Frontali, M., Carella, M., Franco, B., Camaschella, C., & Novelletto, A. (1996). Construction of a YAC contig covering human chromosome 6p22. Genomics, 36(3), 399-407. https://doi.org/10.1006/geno.1996.0484