Consumption of fish and meats and risk of hepatocellular carcinoma

The European prospective investigation into cancer and nutrition (EPIC)

V. Fedirko, A. Trichopolou, C. Bamia, T. Duarte-Salles, E. Trepo, K. Aleksandrova, U. Nöthlings, A. Lukanova, P. Lagiou, P. Boffetta, D. Trichopoulos, V. A. Katzke, K. Overvad, A. Tjønneland, L. Hansen, M. C. Boutron-Ruault, G. Fagherazzi, N. Bastide, S. Panico, S. Grioni & 24 others P. Vineis, D. Palli, R. Tumino, H. B. Bueno-de-Mesquita, P. H. Peeters, G. Skeie, D. Engeset, C. L. Parr, P. Jakszyn, M. J. Sánchez, A. Barricarte, P. Amiano, M. Chirlaque, J. R. Quirós, M. Sund, M. Werner, E. Sonestedt, U. Ericson, T. J. Key, K. T. Khaw, P. Ferrari, I. Romieu, E. Riboli, M. Jenab

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: While higher intake of fish and lower consumption of red/processed meats have been suggested to play a protective role in the etiology of several cancers, prospective evidence for hepatocellular carcinoma (HCC) is limited, particularly in Western European populations. Methods: The associations of fish and meats with HCC risk were analyzed in the EPIC cohort. Between 1992 and 2010, 191 incident HCC were identified among 477 206 participants. Baseline diet was assessed using validated dietary questionnaires. A single 24-h diet recall from a cohort subsample was used for calibration. Multivariable proportional hazard regression was utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI). In a nested case-control subset (HCC = 122), HBV/HCV status and liver function biomarkers were measured.Results: HCC risk was inversely associated with intake of total fish (per 20 g/day increase, HR = 0.83, 95% CI 0.74- 0.95 and HR = 0.80, 95% CI 0.69-0.97 before and after calibration, respectively). This inverse association was also suggested after adjusting for HBV/HCV status and liver function score (per 20-g/day increase, RR = 0.86, 95% CI 0.66-1.11 and RR = 0.74, 95% CI 0.50-1.09, respectively) in a nested case-control subset. Intakes of total meats or subgroups of red/processed meats, and poultry were not associated with HCC risk. Conclusions: In this large European cohort, total fish intake is associated with lower HCC risk.

Original languageEnglish
Pages (from-to)2166-2173
Number of pages8
JournalAnnals of Oncology
Volume24
Issue number8
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Meat
Hepatocellular Carcinoma
Fishes
Confidence Intervals
Neoplasms
Calibration
Diet
Liver
Poultry
Biomarkers
Population

Keywords

  • Cohort study
  • Diet
  • Fish intake
  • Hepatocellular carcinoma
  • Meat intake

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Fedirko, V., Trichopolou, A., Bamia, C., Duarte-Salles, T., Trepo, E., Aleksandrova, K., ... Jenab, M. (2013). Consumption of fish and meats and risk of hepatocellular carcinoma: The European prospective investigation into cancer and nutrition (EPIC). Annals of Oncology, 24(8), 2166-2173. https://doi.org/10.1093/annonc/mdt168

Consumption of fish and meats and risk of hepatocellular carcinoma : The European prospective investigation into cancer and nutrition (EPIC). / Fedirko, V.; Trichopolou, A.; Bamia, C.; Duarte-Salles, T.; Trepo, E.; Aleksandrova, K.; Nöthlings, U.; Lukanova, A.; Lagiou, P.; Boffetta, P.; Trichopoulos, D.; Katzke, V. A.; Overvad, K.; Tjønneland, A.; Hansen, L.; Boutron-Ruault, M. C.; Fagherazzi, G.; Bastide, N.; Panico, S.; Grioni, S.; Vineis, P.; Palli, D.; Tumino, R.; Bueno-de-Mesquita, H. B.; Peeters, P. H.; Skeie, G.; Engeset, D.; Parr, C. L.; Jakszyn, P.; Sánchez, M. J.; Barricarte, A.; Amiano, P.; Chirlaque, M.; Quirós, J. R.; Sund, M.; Werner, M.; Sonestedt, E.; Ericson, U.; Key, T. J.; Khaw, K. T.; Ferrari, P.; Romieu, I.; Riboli, E.; Jenab, M.

In: Annals of Oncology, Vol. 24, No. 8, 08.2013, p. 2166-2173.

Research output: Contribution to journalArticle

Fedirko, V, Trichopolou, A, Bamia, C, Duarte-Salles, T, Trepo, E, Aleksandrova, K, Nöthlings, U, Lukanova, A, Lagiou, P, Boffetta, P, Trichopoulos, D, Katzke, VA, Overvad, K, Tjønneland, A, Hansen, L, Boutron-Ruault, MC, Fagherazzi, G, Bastide, N, Panico, S, Grioni, S, Vineis, P, Palli, D, Tumino, R, Bueno-de-Mesquita, HB, Peeters, PH, Skeie, G, Engeset, D, Parr, CL, Jakszyn, P, Sánchez, MJ, Barricarte, A, Amiano, P, Chirlaque, M, Quirós, JR, Sund, M, Werner, M, Sonestedt, E, Ericson, U, Key, TJ, Khaw, KT, Ferrari, P, Romieu, I, Riboli, E & Jenab, M 2013, 'Consumption of fish and meats and risk of hepatocellular carcinoma: The European prospective investigation into cancer and nutrition (EPIC)', Annals of Oncology, vol. 24, no. 8, pp. 2166-2173. https://doi.org/10.1093/annonc/mdt168
Fedirko, V. ; Trichopolou, A. ; Bamia, C. ; Duarte-Salles, T. ; Trepo, E. ; Aleksandrova, K. ; Nöthlings, U. ; Lukanova, A. ; Lagiou, P. ; Boffetta, P. ; Trichopoulos, D. ; Katzke, V. A. ; Overvad, K. ; Tjønneland, A. ; Hansen, L. ; Boutron-Ruault, M. C. ; Fagherazzi, G. ; Bastide, N. ; Panico, S. ; Grioni, S. ; Vineis, P. ; Palli, D. ; Tumino, R. ; Bueno-de-Mesquita, H. B. ; Peeters, P. H. ; Skeie, G. ; Engeset, D. ; Parr, C. L. ; Jakszyn, P. ; Sánchez, M. J. ; Barricarte, A. ; Amiano, P. ; Chirlaque, M. ; Quirós, J. R. ; Sund, M. ; Werner, M. ; Sonestedt, E. ; Ericson, U. ; Key, T. J. ; Khaw, K. T. ; Ferrari, P. ; Romieu, I. ; Riboli, E. ; Jenab, M. / Consumption of fish and meats and risk of hepatocellular carcinoma : The European prospective investigation into cancer and nutrition (EPIC). In: Annals of Oncology. 2013 ; Vol. 24, No. 8. pp. 2166-2173.
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title = "Consumption of fish and meats and risk of hepatocellular carcinoma: The European prospective investigation into cancer and nutrition (EPIC)",
abstract = "Background: While higher intake of fish and lower consumption of red/processed meats have been suggested to play a protective role in the etiology of several cancers, prospective evidence for hepatocellular carcinoma (HCC) is limited, particularly in Western European populations. Methods: The associations of fish and meats with HCC risk were analyzed in the EPIC cohort. Between 1992 and 2010, 191 incident HCC were identified among 477 206 participants. Baseline diet was assessed using validated dietary questionnaires. A single 24-h diet recall from a cohort subsample was used for calibration. Multivariable proportional hazard regression was utilized to estimate hazard ratios (HR) and 95{\%} confidence intervals (CI). In a nested case-control subset (HCC = 122), HBV/HCV status and liver function biomarkers were measured.Results: HCC risk was inversely associated with intake of total fish (per 20 g/day increase, HR = 0.83, 95{\%} CI 0.74- 0.95 and HR = 0.80, 95{\%} CI 0.69-0.97 before and after calibration, respectively). This inverse association was also suggested after adjusting for HBV/HCV status and liver function score (per 20-g/day increase, RR = 0.86, 95{\%} CI 0.66-1.11 and RR = 0.74, 95{\%} CI 0.50-1.09, respectively) in a nested case-control subset. Intakes of total meats or subgroups of red/processed meats, and poultry were not associated with HCC risk. Conclusions: In this large European cohort, total fish intake is associated with lower HCC risk.",
keywords = "Cohort study, Diet, Fish intake, Hepatocellular carcinoma, Meat intake",
author = "V. Fedirko and A. Trichopolou and C. Bamia and T. Duarte-Salles and E. Trepo and K. Aleksandrova and U. N{\"o}thlings and A. Lukanova and P. Lagiou and P. Boffetta and D. Trichopoulos and Katzke, {V. A.} and K. Overvad and A. Tj{\o}nneland and L. Hansen and Boutron-Ruault, {M. C.} and G. Fagherazzi and N. Bastide and S. Panico and S. Grioni and P. Vineis and D. Palli and R. Tumino and Bueno-de-Mesquita, {H. B.} and Peeters, {P. H.} and G. Skeie and D. Engeset and Parr, {C. L.} and P. Jakszyn and S{\'a}nchez, {M. J.} and A. Barricarte and P. Amiano and M. Chirlaque and Quir{\'o}s, {J. R.} and M. Sund and M. Werner and E. Sonestedt and U. Ericson and Key, {T. J.} and Khaw, {K. T.} and P. Ferrari and I. Romieu and E. Riboli and M. Jenab",
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pages = "2166--2173",
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TY - JOUR

T1 - Consumption of fish and meats and risk of hepatocellular carcinoma

T2 - The European prospective investigation into cancer and nutrition (EPIC)

AU - Fedirko, V.

AU - Trichopolou, A.

AU - Bamia, C.

AU - Duarte-Salles, T.

AU - Trepo, E.

AU - Aleksandrova, K.

AU - Nöthlings, U.

AU - Lukanova, A.

AU - Lagiou, P.

AU - Boffetta, P.

AU - Trichopoulos, D.

AU - Katzke, V. A.

AU - Overvad, K.

AU - Tjønneland, A.

AU - Hansen, L.

AU - Boutron-Ruault, M. C.

AU - Fagherazzi, G.

AU - Bastide, N.

AU - Panico, S.

AU - Grioni, S.

AU - Vineis, P.

AU - Palli, D.

AU - Tumino, R.

AU - Bueno-de-Mesquita, H. B.

AU - Peeters, P. H.

AU - Skeie, G.

AU - Engeset, D.

AU - Parr, C. L.

AU - Jakszyn, P.

AU - Sánchez, M. J.

AU - Barricarte, A.

AU - Amiano, P.

AU - Chirlaque, M.

AU - Quirós, J. R.

AU - Sund, M.

AU - Werner, M.

AU - Sonestedt, E.

AU - Ericson, U.

AU - Key, T. J.

AU - Khaw, K. T.

AU - Ferrari, P.

AU - Romieu, I.

AU - Riboli, E.

AU - Jenab, M.

PY - 2013/8

Y1 - 2013/8

N2 - Background: While higher intake of fish and lower consumption of red/processed meats have been suggested to play a protective role in the etiology of several cancers, prospective evidence for hepatocellular carcinoma (HCC) is limited, particularly in Western European populations. Methods: The associations of fish and meats with HCC risk were analyzed in the EPIC cohort. Between 1992 and 2010, 191 incident HCC were identified among 477 206 participants. Baseline diet was assessed using validated dietary questionnaires. A single 24-h diet recall from a cohort subsample was used for calibration. Multivariable proportional hazard regression was utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI). In a nested case-control subset (HCC = 122), HBV/HCV status and liver function biomarkers were measured.Results: HCC risk was inversely associated with intake of total fish (per 20 g/day increase, HR = 0.83, 95% CI 0.74- 0.95 and HR = 0.80, 95% CI 0.69-0.97 before and after calibration, respectively). This inverse association was also suggested after adjusting for HBV/HCV status and liver function score (per 20-g/day increase, RR = 0.86, 95% CI 0.66-1.11 and RR = 0.74, 95% CI 0.50-1.09, respectively) in a nested case-control subset. Intakes of total meats or subgroups of red/processed meats, and poultry were not associated with HCC risk. Conclusions: In this large European cohort, total fish intake is associated with lower HCC risk.

AB - Background: While higher intake of fish and lower consumption of red/processed meats have been suggested to play a protective role in the etiology of several cancers, prospective evidence for hepatocellular carcinoma (HCC) is limited, particularly in Western European populations. Methods: The associations of fish and meats with HCC risk were analyzed in the EPIC cohort. Between 1992 and 2010, 191 incident HCC were identified among 477 206 participants. Baseline diet was assessed using validated dietary questionnaires. A single 24-h diet recall from a cohort subsample was used for calibration. Multivariable proportional hazard regression was utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI). In a nested case-control subset (HCC = 122), HBV/HCV status and liver function biomarkers were measured.Results: HCC risk was inversely associated with intake of total fish (per 20 g/day increase, HR = 0.83, 95% CI 0.74- 0.95 and HR = 0.80, 95% CI 0.69-0.97 before and after calibration, respectively). This inverse association was also suggested after adjusting for HBV/HCV status and liver function score (per 20-g/day increase, RR = 0.86, 95% CI 0.66-1.11 and RR = 0.74, 95% CI 0.50-1.09, respectively) in a nested case-control subset. Intakes of total meats or subgroups of red/processed meats, and poultry were not associated with HCC risk. Conclusions: In this large European cohort, total fish intake is associated with lower HCC risk.

KW - Cohort study

KW - Diet

KW - Fish intake

KW - Hepatocellular carcinoma

KW - Meat intake

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U2 - 10.1093/annonc/mdt168

DO - 10.1093/annonc/mdt168

M3 - Article

VL - 24

SP - 2166

EP - 2173

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

IS - 8

ER -